212475-56-4Relevant academic research and scientific papers
Enzyme-instructed self-assembly with photo-responses for the photo-regulation of cancer cells
Zhou, Zhengquan,Xie, Xian,Yi, Qikun,Yin, Wencui,Kadi, Adnan A.,Li, Jinbo,Zhang, Yan
, p. 6892 - 6895 (2017/09/01)
Using a short peptide precursor modified by the biaryltetrazole with intramolecular photo-click reactivity, we realized the photo-regulation of the pericellular nanofibers formed by the enzyme-instructed self-assembly on the cell membrane. Upon light irra
Antagonistic Effect of Acetates in C–N Bond Formation with In Situ Generated Diazonium Salts: A Combined Theoretical and Experimental Study
Fabre, Indira,Perego, Luca Alessandro,Bergès, Julien,Ciofini, Ilaria,Grimaud, Laurence,Taillefer, Marc
supporting information, p. 5887 - 5896 (2016/12/18)
The mechanism of the copper-catalyzed arylation of nitrogen heterocycles using anilines via diazonium salts has been studied by combining DFT and experimental data. A CuI/CuIIIredox mechanism is proposed. Our study has revealed the multiple roles of the acid/base couple AcOH/AcO–. An in situ formed triazene species maintains a low concentration of diazonium salts in the reaction medium, which ensures limited formation of decomposition products. The results of DFT calculations have explained the lower reactivity of imidazole nucleophiles as compared with pyrazole in the arylation reaction.
Ligand effects in the metal catalysed reactions of N-aryldiazoamides: Ylide formation vs. insertion reactions
Moody, Christopher J.,Miah, Soyfur,Slawin, Alexandra M. Z.,Mansfield, Darren J.,Richards, Ian C.
, p. 9689 - 9700 (2007/10/03)
Diazoamides 1a and 1b were prepared from 2-(O-allyl)- and 2-(S-allyl) anilines 2 respectively. Copper(II) catalysed decomposition of 1 resulted in formation of benzofused heterocycles 7 by [2,3]-rearrangement of the intermediate ylide. Rhodium(II) perfluorbutyramide catalysed reaction, however, gave mainly the indoles 8, 9 whereas rhodium(II) acetate catalysed reaction resulted in a mixture of products, with β-lactams formed by intramolecular C-H insertion predominating. Catalysed decomposition of N- pyridyl diazoamide 13 gave the stable pyridinium ylide 14.
