212489-95-7Relevant academic research and scientific papers
Design and synthesis of 7-alkoxy-4-heteroarylamino-3-quinolinecarbonitriles as dual inhibitors of c-Src kinase and nitric oxide synthase
Cao, Xin,You, Qi-Dong,Li, Zhi-Yu,Guo, Qing-Long,Shang, Jing,Yan, Ming,Chern, Ji-Wang,Chen, Men-Ling
, p. 5890 - 5898 (2008/12/21)
Because both c-Src and iNOS are key regulatory enzymes in tumorigenesis, a new series of 4-heteroarylamino-3-quinolinecarbonitriles as potent dual inhibitors of both enzymes were designed, prepared, and evaluated for blocking multiple signaling pathways i
7,8-Disubstituted pyrazolobenzodiazepines
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Page/Page column 8, (2008/06/13)
The present invention provides compounds of formula I wherein R1, R2, R3, R4, and R5 are described herein. The invention also provides syntheses for preparation of such compounds and pharmaceutical compositions containing them. The invention further provides methods for inhibiting kinases, in particular CDK2, for inhibiting angiogenesis, and for treating cancers, in particular breast, colon, prostate, and lung cancer.
