212508-16-2

Upstream product

• 188259-62-3 (1S)-[(1E)-methyl-2-(2-methyl-1,3-thiazol-4-yl)ethynyl]-3-butenyl acetate 
• 212507-90-9 (3R,4S,5S,6S)-5-(tert-Butyl-dimethyl-silanyloxy)-3-(4-methoxy-benzyloxy)-2,2,4,6,10-pentamethyl-undec-10-enal 
• 130199-57-4 ((2S,3S)-3-(1-(benzyloxy)-2-methylpropan-2-yl)oxiran-2-yl)methanol 
• 1026727-14-9 (3R,4R,5S,6S)-2,2,4,6,10-Pentamethyl-undec-10-ene-1,3,5-triol 
• 212509-20-1 (3R,4S,5S,6S)-5-(tert-Butyl-dimethyl-silanyloxy)-3-(4-methoxy-benzyloxy)-2,2,4,6,10-pentamethyl-undec-10-en-1-ol 
• 856170-49-5 (3S,4S,5R,6R)-8-Benzyloxy-3,5,7,7-tetramethyl-6-triethylsilanyloxy-oct-1-en-4-ol 
• 212509-17-6 (E)-3-[(2S,3S)-3-(2-Benzyloxy-1,1-dimethyl-ethyl)-oxiranyl]-acrylic acid ethyl ester 
• 212509-18-7 (2S,3R)-5-Benzyloxy-2,4,4-trimethyl-3-triethylsilanyloxy-pentanal 
• 121352-87-2 (E)-5-(benzyloxy)-4,4-dimethylpent-2-en-1-ol 

Downstream Products

• 152044-54-7 epothilone B 
• 189453-35-8 (4S,7R,8S,9S,13Z,16S,1'E)-4,8-di-tert-butyldimethylsilyloxy-5,5,7,9,13-pentamethyl-16-[1-methyl-2-(2-methyl-1,3-thiazol-4-yl)-1-ethenyl]-1-oxa-13-cyclohexadecene-2,6-dione 
• 189453-10-9 epothilone D 

Relevant academic research and scientific papers

Total synthesis of (-)-epothilone B

The sixteen-membered ring macrolide (-)-epothilone B 1 has been synthesized by a route which features stereospecific methylation of an (E)-γ,δ-epoxy acrylate, the use of a double asymmetric reaction employing (R,R)-diisopropyltartrate and (E)-crotylboronate, and ring closure by means of an olefin metathesis reaction.