130199-57-4Relevant academic research and scientific papers
Stereoselective Synthesis of γ-Butyrolactones Subunit of Polycavernoside A
Kadari, Sudhakar,Yerrabelly, Hemasri,Gogula, Thirupathi,Erukala, Yadaiah Goud,Yerrabelly, Jayaprakash Rao,Begari, Prem Kumar
, p. 1986 - 1990 (2018/08/01)
An efficient and versatile linear synthesis of γ-butyrolactone subunit of polycavernolide A has been reported in 14.2% overall yield with 10 linear steps by employing Sharpless asymmetric epoxidation, ring-closing metathesis, and diastereoface selective h
Total synthesis of (-)-epothilone B
May, Scott A.,Grieco, Paul A.
, p. 1597 - 1598 (2007/10/03)
The sixteen-membered ring macrolide (-)-epothilone B 1 has been synthesized by a route which features stereospecific methylation of an (E)-γ,δ-epoxy acrylate, the use of a double asymmetric reaction employing (R,R)-diisopropyltartrate and (E)-crotylboronate, and ring closure by means of an olefin metathesis reaction.
Synthesis of Bryostatins. 1. Construction of the C(1)-C(16) Fragment
Blanchette, Mary A.,Malamas, Michael S.,Nantz, Michael H.,Roberts, John C.,Somfai, Peter,et al.
, p. 2817 - 2825 (2007/10/02)
The synthesis of fragment AB of bryostatin 1 is described.Two aldol coupling reactions involving (i) chiral fragment A with achiral B and (ii) chiral fragment A1 with achiral A2 constitute crucial steps in which an external chiral boron reagent is used to control stereoselectivity in the creation of a new stereogenic center.This type of double asymmetric synthesis, although rarely precedented, provides a powerful means of stereocontrol over the fragment assembly.
