21262-87-3

Upstream product

• 21262-83-9 [3-(4-bromo-phenyl)-5-methyl-4,5-dihydro-isoxazol-5-yl]-phenyl-methanone 
• 21293-19-6 [3-(4-bromo-phenyl)-5-methyl-4,5-dihydro-isoxazol-5-yl]-phenyl-methanone (Z)-oxime 
• 21293-19-6 [3-(4-bromo-phenyl)-5-methyl-4,5-dihydro-isoxazol-5-yl]-phenyl-methanone (E)-oxime 
• 108-22-5 Isopropenyl acetate 
• 29203-58-5 4-bromo-N-hydroxybenzenecarboximidoyl chloride 
• 57342-22-0 2-bromo-1-(4-bromophenyl)ethanone oxime 
• 3815-31-4 4-(4-bromophenyl)but-3-en-2-one 
• 184165-64-8 1-(4-bromophenyl)-3-buten-1-one 
• 1122-91-4 4-bromo-benzaldehyde 
• 106650-98-0 1-(4-bromophenyl)but-3-en-1-ol 
• 20511-04-0 (E)-4-(4-bromophenyl)but-3-ene-2-one 
• 25062-46-8 4-bromobenzaldehyde Oxime 
• 29203-58-5 (Z)-4-bromo-N-hydroxybenzene-1-carbonimidoyl chloride 

Relevant academic research and scientific papers

CARDIAC SARCOMERE INHIBITORS

Provided are compounds of Formula (I): or a pharmaceutically acceptable salt thereof, wherein R1, R2, Y1, Y2, L1, and G1 are as defined herein. Also provided is a pharmaceutically acceptable composition comprising a compound of Formula (I), or a pharmaceutically acceptable salt thereof. Also provided are methods of using a compound of Formula (I), or a pharmaceutically acceptable salt thereof.

Preparation method for impurity of parecoxib sodium

The invention belongs to the technical field of medicinal chemistry, and in particular relates to a preparation method for an impurity of parecoxib sodium. A synthetic method of the compound PRN073-11is never mentioned in the prior art, a very small amoun

Thienopyrimidine derivative, preparation method thereof and application thereof in medicines

The invention provides a thienopyrimidine derivative, a preparation method thereof and an application thereof in medicines. Specifically, the invention relates to a compound represented by a formula I, wherein the radicals are defined in the description. The compound is effective tyrosine kinase inhibitors in one category, and is particularly suitable for being used as an EGFR and/or HER2 inhibitor.

Oxime-mediated facile access to 5-methylisoxazoles and applications in the synthesis of valdecoxib and oxacillin

A palladium-catalyzed efficient synthesis of 5-methylisoxazoles via oxime-mediated functionalization of unactivated olefins is described. The reaction affords a variety of 5-methylisoxazoles in moderate to good yields. To further demonstrate the utility of the method, the rapid synthesis of valdecoxib and oxacillin is reported. (Chemical Equation Presented).

Efficient and regioselective one-pot synthesis of 3-substituted and 3,5-disubstituted isoxazoles

(Figure Presented) A series of 3-substituted and 3,5-disubstituted isoxazoles have been efficiently synthesized in moderate to excellent yields by the reaction of N-hydroxyl-4-toluenesulfonamide with α,β-unsaturated aldehydes/ketones. This novel strategy is associated with readily available starting materials, mild conditions, high regioselectivity, and wide scope.

The synthesis of isoxazoles from β,γ-acetylenic oximes

β,γ-Acetylenic oximes (prepared from α-bromooximes) undergo facile conversion to 3,5-disubstituted isoxazoles on mild base treatment.