212645-24-4

Upstream product

• 212645-22-2 (E)-1-chloro-5-(4-methoxybenzyloxy)pent-2-ene 
• 158817-21-1 (E)-5-(4-methoxybenzyloxy)pent-2-en-1-ol 
• 1235570-36-1 (S)-2-(4-(4-methoxybenzyloxy)butan-2-yl)-1,3-dithiane 

Downstream Products

• 1235570-37-2 (2S,3S)-1,2-epoxy-3-(ethoxymethoxy)-5-(4-methoxybenzyloxy)pentane 
• 1235570-39-4 (S)-1-(tert-butyldimethylsilyloxy)-3-(2-((2'S,3'S)-3'-(ethoxymethoxy)-2'-hydroxy-5'-(4-methoxybenzyloxy)pentane-1'-yl)-1,3-dithian-2-yl)butane 
• 1235570-40-7 (S)-3-(2-((2'S,3'S)-2'-(benzyloxy)-3'-(ethoxymethoxy)-5'-(4-methoxybenzyloxy)pentan-1'-yl)-1,3-dithian-2-yl)butan-1-ol 
• 1235570-41-8 (S)-3-(2-((2'S,3'S)-2'-(benzyloxy)-3'-(ethoxymethoxy)-5'-(4-methoxybenzyloxy)pentane-1'-yl)-1,3-dithian-2-yl)butanal 
• 1235570-44-1 (1S,2S)-3-(2-((2'S,3'S)-2'-(benzyloxy)-3'-(ethoxymethoxy)-5'-(4-methoxybenzyloxy)-pentan-1'-yl)-1,3-dithian-2-yl)-1-(2-((2''S,4''S)-5''-(tert-butyldiphenylsilyloxy)-4''-(ethoxymethoxy)-2''-methoxypentan-1''-yl)-1,3-dithian-2-yl)butan-1-ol 
• 1339911-23-7 (1R,3S)-3-(2-((2'S,3'S)-2'-(benzyloxy)-3'-(ethoxymethoxy)-5'-(4-methoxybenzyloxy)-pentan-1'-yl)-1,3-dithian-2-yl)-1-(2-((2''S,4''S)-5''-(tert-butyldiphenylsilyloxy)-4''-(ethoxymethoxy)-2''-methoxypentan-1''-yl)-1,3-dithian-2-yl)butan-1-ol 
• 1235570-45-2 (2S,3S,5R,7S,9S,11S,13S,15S)-3-(benzyloxy)-9-((tert-butyldiphenylsilyloxy)methyl)-2-(1'-(4-methoxybenzyloxy)ethan-2'-yl)-13-hydroxy-11-methoxy-15-methyl-1,6,8-trioxadispiro[4.1.5.3]pentadecane 
• 1235570-32-7 (S)-3-(2-((2'S,3'S)-2'-(benzyloxy)-3'-(ethoxymethoxy)-5'-(4-methoxybenzyloxy)pentan-1'-yl)-1,3-dithian-2-yl)-1-(tert-butyldimethylsilyloxy)butane 
• 212645-26-6 (2S,3S)-1,2-epoxy-5-(4-methoxybenzyloxy)-3-pentanol 
• 1339911-24-8 (1R,3S)-3-(2-((2'S,3'S)-2'-(benzyloxy)-3'-(ethoxymethoxy)-5'-(4-methoxybenzyloxy)-pentan-1'-yl)-1,3-dithian-2-yl)-1-(2-((2''S,4''S)-5''-(tert-butyldiphenylsilyloxy)-4''-(ethoxymethoxy)-2''-methoxypentan-1''-yl)-1,3-dithian-2-yl)-1-methoxybutane 
• 1339911-31-7 (1R,3S)-3-(2-((2'S,3'S)-2'-(benzyloxy)-3'-hydroxy-5'-(4-methoxybenzyloxy)-pentan-1'-yl)-1,3-dithian-2-yl)-1-(2-((2''S,4''S)-5''-(tert-butyldiphenylsilyloxy)-4''-hydroxy-2''-methoxypentan-1''-yl)-1,3-dithian-2-yl)-1-methoxybutane 
• 1339911-25-9 (2S,3S,5R,7S,9S,11S,13R,15S)-3-(benzyloxy)-9-((tert-butyldiphenylsilyloxy)methyl)-2-(1'-(4-methoxybenzyloxy)ethan-2'-yl)-11-methoxy-13-methoxy-15-methyl-1,6,8-trioxadispiro[4.1.5.3]pentadecane 
• 1339911-26-0 (2S,4S)-6-((2S,4S,5R,7S,8S)-8-(benzyloxy)-7-(2-((4-methoxybenzyl)oxy)ethyl)-4-methyl-1,6-dioxaspiro[4.4]nonan-2-yl)-1-((tert-butyldiphenylsilyl)oxy)-4-methoxy-6-oxohexan-2-yl 1H-imidazole-1-carbothioate 

Relevant academic research and scientific papers

Synthesis of the bis-spiroacetal core of the antimitotic agent spirastrellolide B

The spirastrellolides are a family of potent antimitotic agents isolated from the marine sponge Spirastrella coccinea. Synthetic studies toward the DEF bis-spiroacetal core of spirastrellolide B are reported. A modular approach was pursued by the use of t

Synthesis of the bis-spiroacetal C25-C40 moiety of the antimitotic agent spirastrellolide B using a bis-dithiane deprotection/spiroacetalisation sequence

Use of a bis-dithiane deprotection-tandem bis-spiroacetalisation sequence was key to the successful synthesis of the [5,6,6]-bis-spiroacetal of the antimitotic agent spirastrellolide B, achieved in a highly convergent fashion involving successive dithiane alkylations.