1235570-45-2

Upstream product

• 212645-22-2 (E)-1-chloro-5-(4-methoxybenzyloxy)pent-2-ene 
• 158817-21-1 (E)-5-(4-methoxybenzyloxy)pent-2-en-1-ol 
• 102778-93-8 (2S,4S)-5-(tert-Butyl-diphenyl-silanyloxy)-pentane-1,2,4-triol 
• 92512-41-9 C₂₁H₂₈O₃Si 
• 212645-26-6 (2S,3S)-1,2-epoxy-5-(4-methoxybenzyloxy)-3-pentanol 
• 1235570-47-4 (S)-2-(1,3-dithian-2-yl)butan-4-ol 
• 1235570-37-2 (2S,3S)-1,2-epoxy-3-(ethoxymethoxy)-5-(4-methoxybenzyloxy)pentane 
• 212645-24-4 (2R,3S)-1-chloro-5-(4-methoxybenzyloxy)pentane-2,3-diol 
• 1235570-38-3 (S)-2-(4-(tert-butyldimethylsilyloxy)butan-2-yl)-1,3-dithiane 
• 1235570-36-1 (S)-2-(4-(4-methoxybenzyloxy)butan-2-yl)-1,3-dithiane 
• 1235570-48-5 (2S,4S)-1-(tert-butyldiphenylsilyloxy)-5-(1,3-dithian-2-yl)-2-(ethoxymethoxy)-4-pentanol 
• 1235570-32-7 (S)-3-(2-((2'S,3'S)-2'-(benzyloxy)-3'-(ethoxymethoxy)-5'-(4-methoxybenzyloxy)pentan-1'-yl)-1,3-dithian-2-yl)-1-(tert-butyldimethylsilyloxy)butane 
• 1235570-44-1 (1S,2S)-3-(2-((2'S,3'S)-2'-(benzyloxy)-3'-(ethoxymethoxy)-5'-(4-methoxybenzyloxy)-pentan-1'-yl)-1,3-dithian-2-yl)-1-(2-((2''S,4''S)-5''-(tert-butyldiphenylsilyloxy)-4''-(ethoxymethoxy)-2''-methoxypentan-1''-yl)-1,3-dithian-2-yl)butan-1-ol 
• 1235570-35-0 (2S,4S)-1-(tert-butyldiphenylsilyloxy)-5-(1,3-dithian-2-yl)-2-(ethoxymethoxy)-4-methoxypentane 

Downstream Products

• 1235570-50-9 (2S,3S,5R,7S,9S,11S,13S,15S)-3-(benzyloxy)-9-((tert-butyldiphenylsilyloxy)methyl)-2-(1'-(4-methoxybenzyloxy)ethan-2'-yl)-11-methoxy-15-methyl-1,6,8-trioxadispiro[4.1.5.3]pentadecan-13-yl imidazole-1-carbothioate 
• 1339911-26-0 (2S,4S)-6-((2S,4S,5R,7S,8S)-8-(benzyloxy)-7-(2-((4-methoxybenzyl)oxy)ethyl)-4-methyl-1,6-dioxaspiro[4.4]nonan-2-yl)-1-((tert-butyldiphenylsilyl)oxy)-4-methoxy-6-oxohexan-2-yl 1H-imidazole-1-carbothioate 

Relevant academic research and scientific papers

Synthesis of the bis-spiroacetal core of the antimitotic agent spirastrellolide B

The spirastrellolides are a family of potent antimitotic agents isolated from the marine sponge Spirastrella coccinea. Synthetic studies toward the DEF bis-spiroacetal core of spirastrellolide B are reported. A modular approach was pursued by the use of t

Synthesis of the bis-spiroacetal C25-C40 moiety of the antimitotic agent spirastrellolide B using a bis-dithiane deprotection/spiroacetalisation sequence

Use of a bis-dithiane deprotection-tandem bis-spiroacetalisation sequence was key to the successful synthesis of the [5,6,6]-bis-spiroacetal of the antimitotic agent spirastrellolide B, achieved in a highly convergent fashion involving successive dithiane alkylations.