212645-22-2Relevant academic research and scientific papers
Synthesis of the bis-spiroacetal core of the antimitotic agent spirastrellolide B
Chen, Jack Li-Yang,Brimble, Margaret A.
experimental part, p. 9417 - 9428 (2012/01/13)
The spirastrellolides are a family of potent antimitotic agents isolated from the marine sponge Spirastrella coccinea. Synthetic studies toward the DEF bis-spiroacetal core of spirastrellolide B are reported. A modular approach was pursued by the use of t
Application of the 2-azaallyl anion cycloaddition method to an enantioselective total synthesis of (+)-coccinine
Pearson, William H.,Lian, Brian W.
, p. 1724 - 1726 (2007/10/03)
A highly functionalized perhydroindole is formed by the intramolecular [π4s+π2s] cycloaddition of a 2-azaallyl anion with a vinyl sulfide [Eq. (a)]. This is the key step in the total synthesis of (+)-coccinine, the enantiomer of the Amaryllidaceae alkaloi
