212688-02-3Relevant academic research and scientific papers
Synthesis of (+)-O-methylthalibrine by employing a stereocontrolled Bischler-Napieralski reaction and an electrochemically generated diaryl ether
Kawabata, Yuki,Naito, Yu,Saitoh, Tsuyoshi,Kawa, Kohei,Fuchigami, Toshio,Nishiyama, Shigeru
, p. 99 - 104 (2014/01/06)
An efficient electrochemical four-step route was developed for the preparation of diaryl ether derivatives by using halogenation and dehalogenation processes in addition to electrochemical phenolic oxidation and reduction reactions. The synthesis of (+)-O
Electrochemical construction of the diaryl ethers: A synthetic approach to o-methylthalibrine
Naito, Yu,Tanabe, Takamasa,Kawabata, Yuki,Ishikawa, Yuichi,Nishiyama, Shigeru
body text, p. 4776 - 4778 (2010/09/20)
Electrochemical dimerization of halogenated p-hydroxyphenylacetic acid derivatives followed by Zn reduction provided the corresponding diaryl ethers. Manipulation of the reduction step using several procedures increased its efficiency, which enabled the construction of o-methylthalibrine, an isoquinoline-class alkaloid.
Total synthesis of antibacterial dibromotyrosine derived alkaloid purpuramine-K#
Reddy, S. Malla,Srinivasulu,Venkateswarlu
, p. 2757 - 2762 (2007/10/03)
The first total synthesis of a dibromotyrosine derived alkaloid purpuramine K 1 reported for possible anti-bacterial activity against gram-positive bacteria viz: Staphylococcus aureus, Bacillus subtilis, Bacillus sphaericus and gram-negative bacteria like Chromobacterium violaceum, Klebsiella aerogenes, and Pseudomonas aeruginosa has been achieved. The synthesis involves preparation of methyl-3-bromopropyl carbamate 6, and Boc protected 2-[3,5-dibromo, 4-hydroxy phenyl] ethyl amine 13 which is followed by coupling of these two structural fragments to give corresponding ether 14. After deprotection of Boc group in compound 14, it is reacted with 4-hydroxyphenyl pyruvic acid oxime derivative 17 using EDCI/HOBT to give compound 18, which is further transformed to purpuramine K.
Thyroid receptor ligands. Part 2: Thyromimetics with improved selectivity for the thyroid hormone receptor beta
Hangeland, Jon J.,Doweyko, Arthur M.,Dejneka, Tamara,Friends, Todd J.,Devasthale, Pratik,Mellstroem, Karin,Sandberg, Johnny,Grynfarb, Marlena,Sack, John S.,Einspahr, Howard,Faernegardh, Mathias,Husman, Bolette,Ljunggren, Jan,Koehler, Konrad,Sheppard, Cheryl,Malm, Johan,Ryono, Denis E.
, p. 3549 - 3553 (2007/10/03)
A set of thyromimetics having improved selectivity for TR-β1 were prepared by replacing the 3′-isopropyl group of 2 and 3 with substituents having increased steric bulk. From this limited SAR study, the most potent and selective compounds ident
Thyroid receptor ligands and method
-
, (2008/06/13)
Novel thyroid receptor ligands are provided which have the general formula (I) where R1is alkyl of 1 to 4 carbons or cycloalkyl of 3 to 7 carbons; R2and R3are the same or different and are hydrogen, halogen, alkyl of 1 to
Syntheses of the marine metabolites verongamine, hemibastadin-2, and aerothionin using the cyano ylide coupling methodology
Wasserman, Harry H.,Wang, Jianji
, p. 5581 - 5586 (2007/10/03)
Syntheses of the marine metabolites verongamine, hemibastadin-2, and aerothionin have been accomplished by a methodology involving the conversion of a carboxylic acid to an acyl cyano phosphorane which may be oxidized to an α,β-diketo nitrile. This strong
