21282-90-6

Basic information

• Product Name: 6-(4-AMinophenyl)-4,5-dihydro-3(2H)-pyridazinone
• Synonyms: 6-(4-AMinophenyl)-4,5-dihydro-3(2H)-pyridazinone;6-(p-Aminophenyl)-4,5-dihydro-3(2H)-pyridazinone;6-p-Aminophenyl-4,5-dihydro-3-pyridazone;6-(4-AMINOPHENYL)-2,3,4,5-TETRAHYDROPYRIDAZIN-3-ONE(WXG02067);6-(4-AMINOPHENYL)-2,3,4,5-TETRAHYDROPYRIDAZIN-3-ONE
• CAS NO: 21282-90-6
• Molecular Formula: C₁₀H₁₁N₃O
• Molecular Weight: 189.21384
• EINECS: -0
• Mol File: 21282-90-6.mol
• Article Data: 8

Chemical Properties

• Melting Point: 240-241℃
• Appearance: /
• Density: 1.35
• PKA: 13.87±0.40(Predicted)
• CAS DataBase Reference: 6-(4-AMinophenyl)-4,5-dihydro-3(2H)-pyridazinone(CAS DataBase Reference)
• NIST Chemistry Reference: 6-(4-AMinophenyl)-4,5-dihydro-3(2H)-pyridazinone(21282-90-6)
• EPA Substance Registry System: 6-(4-AMinophenyl)-4,5-dihydro-3(2H)-pyridazinone(21282-90-6)

Safety Data

• Hazardous Substances Data: 21282-90-6(Hazardous Substances Data)

Upstream product

• 21394-91-2 N-(4-(6-oxo-1,4,5,6-tetrahydropyridazin-3-yl)phenyl)acetamide 
• 103-84-4 Acetanilid 
• 5473-15-4 4-(4-acetamidophenyl)-4-oxobutanoic acid 
• 6945-94-4 4-(4-amino-phenyl)-4-oxo-butyric acid 

Downstream Products

• 67322-78-5 2-methyl-1,1,4-trioxo-1,2,3,4-tetrahydro-1λ⁶-benzo[e][1,2]thiazine-3-carboxylic acid 4-(6-oxo-1,4,5,6-tetrahydro-pyridazin-3-yl)-anilide 
• 85234-89-5 N-[4-(6-Oxo-1,4,5,6-tetrahydro-pyridazin-3-yl)-phenyl]-butyramide 
• 39754-33-1 6-[4-(2-chloro-propionylamino)-phenyl]-4,5-dihydro-2H-pyridazin-3-one 
• 111794-33-3 6-<4-(3-bromopropionamido)phenyl>-4,5-dihydro-3(2H)-pyridazinone 
• 86798-60-9 4,5-dihydro-6-<4-isothiocyanatophenyl>-3(2H)-pyridazinone 
• 97150-77-1 N,N'-bis<4-(1,4,5,6-tetrahydro-6-oxo-3-pyridazinyl)phenyl>thiourea 
• 128995-88-0 6-[4-(1-(2,4-dihydroxyphenyl)-2-(4-hydroxyphenyl)ethylidene)aminophenyl]-4,5-dihydropyridazin-3(2H)one 
• 128995-84-6 6-[4-(1-(4-Pyridyl)ethylidene)aminophenyl]-4,5-dihydropyridazin-3(2H)one 
• 128995-83-5 6-[4-(1-(2,4-Dihydroxyphenyl)propylidene)aminophenyl]-4,5-dihydropyridazin-3(2H)one 
• 131741-14-5 C₁₆H₁₈N₄O₄ 
• 131741-05-4 C₁₅H₁₅N₅O₃ 
• 1221170-24-6 C₂₁H₂₀N₆O 
• 1221170-25-7 6-{4-[2-(3-amino-5-oxo-pyrazolin-4-ylidene)hydrazino]phenyl}-4,5-dihydro-3(2H)-pyridazinone 
• 1221170-26-8 6-{4-[2-(1-N-methylcarbamoyl-1-{1-(N-methylimino)ethyl}-methylidene)-hydrazino]phenyl}-4,5-dihydro-3(2H)-pyridazinone 

Relevant articles and documents

NOVEL HYDRAZONE DERIVATIVE WITH ARYL OR HETEROARYL GROUP SUBSTITUTED AT TERMINAL AMINE GROUP THEREOF AND USE THEREOF

The present invention relates to novel hydrazone derivatives in which a terminal amine group is substituted with an aryl group or a heteroaryl group, and uses thereof.

Design, synthesis and molecular modeling of phenyl dihydropyridazinone derivatives as B-Raf inhibitors with anticancer activity

Three new series of phenyl dihydropyridazinone derivatives 4b–8i have been designed, synthesized and evaluated for their anticancer activity against different cancer cell lines. Nine compounds showed strong inhibitory activity, among which compound 8b exh

Synthesis and bioactivity of 6-phenyl-4,5-dihydro-3(2H)-pyridazinone derivatives

A series of 6-phenyl-4,5-dihydro-3(2H)-pyridazinone derivatives was prepared and examined for cardiotonic activity. The structures of these new pyridazinone derivatives were confirmed by IR, 1H-NMR and mass spectrum. The cardiotonic activities of these compounds were studied on isolated perfused toad heart and compared with the activity of levosimendan (CAS 141505-33-1). Compound 5a emerged as the most interesting compound in this series with potential cardiotonic activity. ECV Editio Cantor Verlag.