21286-60-2

Basic information

• Product Name: (2R,6R,11R)-3,6,11-Trimethyl-1,2,3,4,5,6-hexahydro-2,6-methano-benzo[d]azocin-8-ol
• CAS NO: 21286-60-2
• Molecular Weight: 231.338
• Mol File: 21286-60-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (2R,6R,11R)-3,6,11-Trimethyl-1,2,3,4,5,6-hexahydro-2,6-methano-benzo[d]azocin-8-ol(CAS DataBase Reference)
• NIST Chemistry Reference: (2R,6R,11R)-3,6,11-Trimethyl-1,2,3,4,5,6-hexahydro-2,6-methano-benzo[d]azocin-8-ol(21286-60-2)
• EPA Substance Registry System: (2R,6R,11R)-3,6,11-Trimethyl-1,2,3,4,5,6-hexahydro-2,6-methano-benzo[d]azocin-8-ol(21286-60-2)

Safety Data

• Hazardous Substances Data: 21286-60-2(Hazardous Substances Data)

Upstream product

• 577991-79-8 3-((R)-7-Methoxy-1-methyl-2-methylene-1,2,3,4-tetrahydro-naphthalen-1-yl)-propane-1,2-diol 
• 577991-75-4 [2-((R)-7-Methoxy-1-methyl-2-methylene-1,2,3,4-tetrahydro-naphthalen-1-yl)-ethyl]-methyl-amine 
• 577991-73-2 (R)-1-Allyl-7-methoxy-1-methyl-2-methylene-1,2,3,4-tetrahydro-naphthalene 
• 577991-72-1 1-allyl-7-methoxy-1-methyl-2-tetralone 
• 577991-74-3 ((R)-7-Methoxy-1-methyl-2-methylene-1,2,3,4-tetrahydro-naphthalen-1-yl)-acetaldehyde 
• 1204-23-5 1-methyl-7-methoxy-2-tetralone 
• 64023-75-2 O-methyl metazocine 
• 74-83-9 methyl bromide 
• 16603-67-1 (2R,6R,11R)-6,11-dimethyl-1,2,3,4,5,6-hexahydro-2,6-methano-benzo[d]azocin-8-ol 
• 50-00-0 formaldehyd 
• 16603-67-1 (-)-cis-N-Normetazocine 
• 38769-92-5 4-methoxybenzylmagnesium chloride 
• 6283-41-6 1,3,4-trimethylpyridinium iodide 
• 2651-64-1 (+/-)-3,6,11syn-trimethyl-8-nitro-1,2,3,4,5,6-hexahydro-2,6-methano-benz[d]azocine; hydrochloride 

Downstream Products

• 83434-66-6 Thiobenzoic acid S-((2R,6R,11R)-3,6,11-trimethyl-1,2,3,4,5,6-hexahydro-2,6-methano-benzo[d]azocin-8-yl) ester 
• 71780-67-1 Thiobenzoic acid S-((6R,11R)-3,6,11-trimethyl-1,2,3,4,5,6-hexahydro-2,6-methano-benzo[d]azocin-8-yl) ester 
• 83434-66-6 Thiobenzoic acid S-((2R,6R,11R)-3,6,11-trimethyl-1,2,3,4,5,6-hexahydro-2,6-methano-benzo[d]azocin-8-yl) ester 
• 127-35-5 (+)-6,11syn-dimethyl-3-phenethyl-1,2,3,4,5,6-hexahydro-2,6-methano-benz[d]azocin-8-ol 

Relevant articles and documents

Migratory hydroamination: A facile enantioselective synthesis of benzomorphans

We describe a highly efficient, general strategy for the enantioselective synthesis of benzomorphans (45-46% overall yield from commercially available material). The new synthesis demonstrates the effectiveness of an unprecedented diastereoselective cycloisomerization via migratory hydroamination and the power of palladium-catalyzed asymmetric allylic alkylation (AAA) of simple ketone enolates in the context of complex synthesis. The strategy outlined here for the enantioselective synthesis of three contiguous stereogenic centers and the novel cycloisomerization should have many applications in alkaloid synthesis. Copyright

An improved resolution of (±)-cis-N-normetazocine

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