212912-09-9Relevant articles and documents
Synthesis and anti-HIV activity of α-thiophenoxy-hydroxyethylamide derivatives
Medou, Martial,Priem, Ghislaine,Rocheblave, Luc,Pepe, Gerard,Meyer, Monique,Chermann, Jean-Claude,Kraus, Jean-Louis
, p. 625 - 638 (2007/10/03)
A series of new anti-HIV derivatives containing a novel α- thiophenoxyhydroxyethylamide core have been synthesized, using S- phenylbenzenethiosulfonate as the thiosulfenylating reagent. Some of the new synthesized compounds (1a, 1c, 1g, 1i, 1j and 1l) inhibited HIV replication in cell culture assays (syncytia formation) with effective concentrations (EC50) ranging from 0. 1-1 μM. Incorporation of thiophenoxy substitution within various pseudomimetic peptide backbones provided a series of highly potent HIV inhibitors.