212912-11-3Relevant academic research and scientific papers
Synthesis and anti-HIV activities of symmetrical N1,N3-dibenzyl-2- hydroxy-propane derivatives
Medou,Bouygues,Rocheblave,Chermann,Kraus
, p. 1861 - 1866 (1998)
We report the synthesis and the anti-HIV activities of new C2- symmetrical and achiral N1,N3-dibenzyl-2-hydroxy-propane isosteres. Some of them showed significant inhibitory activity with respect to HIV-infected MT4 cells
Synthesis and anti-HIV activity of α-thiophenoxy-hydroxyethylamide derivatives
Medou, Martial,Priem, Ghislaine,Rocheblave, Luc,Pepe, Gerard,Meyer, Monique,Chermann, Jean-Claude,Kraus, Jean-Louis
, p. 625 - 638 (2007/10/03)
A series of new anti-HIV derivatives containing a novel α- thiophenoxyhydroxyethylamide core have been synthesized, using S- phenylbenzenethiosulfonate as the thiosulfenylating reagent. Some of the new synthesized compounds (1a, 1c, 1g, 1i, 1j and 1l) inhibited HIV replication in cell culture assays (syncytia formation) with effective concentrations (EC50) ranging from 0. 1-1 μM. Incorporation of thiophenoxy substitution within various pseudomimetic peptide backbones provided a series of highly potent HIV inhibitors.
