21298-54-4Relevant articles and documents
Synthesis and spectral properties of 5,5'-di(4-pyridyl)-2,2'-bithienyl as a new fluorescent compound
Nakajima,Iida,Hara
, p. 636 - 637 (1990)
A new type of fluorescent compound, 5,5'-di(4-pyridyl)-2,2'-bithienyl, has been synthesized and its fluorescence intensity measured at 510 nm in a 40% aqueous methanol (pH3.0) with excitation at 425 nm. The quantum yield was found to be 0.52. The thienylpyridine skeleton was found for the first time as a new fluorophore.
Metal-Free Aerobic Oxidative Selective C-C Bond Cleavage in Heteroaryl-Containing Primary and Secondary Alcohols
Xia, Anjie,Qi, Xueyu,Mao, Xin,Wu, Xiaoai,Yang, Xin,Zhang, Rong,Xiang, Zhiyu,Lian, Zhong,Chen, Yingchun,Yang, Shengyong
, (2019/05/07)
A transition-metal-free aerobic oxidative selective C-C bond-cleavage reaction in primary and secondary heteroaryl alcohols is reported. This reaction was highly efficient and tolerated various heteroaryl alcohols, generating a carboxylic acid derivative and a neutral heteroaromatic compound. Experimental studies combined with density functional theory calculations revealed the mechanism underlying the selective C-C bond cleavage. This strategy also provides an alternative simple approach to carboxylation reaction.
Copper-catalyzed Hiyama coupling of (hetero)aryltriethoxysilanes with (hetero)aryl iodides
Gurung, Santosh K.,Thapa, Surendra,Vangala, Adarsh S.,Giri, Ramesh
supporting information, p. 5378 - 5381 (2013/11/06)
A CuI-catalyzed Hiyama coupling was achieved, which proceeds in the absence of an ancillary ligand for aryl-heteroaryl and heteroaryl-heteroaryl couplings. A P,N-ligand is required to obtain the best product yields for aryl-aryl couplings. In addition to facilitating transmetalation, CsF is also found to function as a stabilizer of the [CuAr] species, potentially generated as an intermediate after transmetalation of aryltriethoxysilanes with Cu I-catalysts in the absence of ancillary ligands.
Radical dearomatization of arenes and heteroarenes
Crich, David,Patel, Mitesh
, p. 7824 - 7837 (2007/10/03)
The stannane-mediated benzeneselenol-catalyzed addition of aryl iodides to a range of arenes and aromatic hetereocycles has been studied. With furan, thiophene, and several carbocyclic arenes, the addition takes place with quenching of the adduct radical by the catalytic selenol leading to moderate yields of aryl-dihydroarenes. With nitrogen heterocycles, on the other hand, it was not possible to suppress aromatization of the adduct radical and fully aromatized products were isolated. Aryl iodides bearing hydrogen bond donating groups in the ortho-position add to nitrogen heterocycles with high selectivity ortho- to the nitrogen, affording a simple one-step synthesis of potential chelating ligands. While 2-iodophenol is an excellent aryl radical source in these reactions, the homologous 1-iodo-2-naphthol fails owing to its reaction with diphenyl diselenide, which gives 1-phenylseleno-2-naphthol in high yield.
Direct synthesis of heterobiaryls by radical addition to pyridine: Expeditious synthesis of chelating ligands
Crich, David,Patel, Mitesh
, p. 499 - 504 (2007/10/03)
The addition of aryl radicals to pyridine may be affected in moderate yield on exposure of aryl iodides to tributyltin hydride, AIBN, and diphenyl diselenide in hot pyridine. Mixtures of ortho-, meta-, and para-aryl substituted pyridines are typically obtained. When the iodide is ortho-substituted with a hydrogen bond donor, such as o-iodophenol, significantly improved selectivity for ortho-substituted pyridines, with potential as bidentate chelating ligands, is obtained.
Piperazine compounds as inhibitors of MMP or TNF
-
, (2008/06/13)
A compound of formula (I) wherein A is a sulfonyl or a carbonyl; R1is an optionally substituted aryl, an optionally substituted heterocyclic group, an optionally substituted lower alkyl or an optionally substituted lower alkenyl; R2is a hydrogen, an optionally substituted lower alkyl, an optionally substituted aryl or an optionally substituted heterocyclic group; R3is an optionally substituted lower alkyl, an optionally substituted lower alkoxy, an optionally substituted aryloxy, an optionally substitued lower alkenyl, an optionally substituted aryl, an optionally substituted heterocyclic group or an optionally substitued amino; R4is a hydrogen, an optionally substituted lower alkyl, an optionally substituted aryl or an optionally substituted heterocyclic group; R5is a hydrogen, an optionally substituted lower alkyl, an optionally substituted aryl or an optionally substituted heterocyclic group; and R10is a hydroxy or a protected hydroxy, and a pharmaceutically acceptable salt thereof. The compound of the present invention is useful as a medicament for prophylactic and therapeutic treatment of MMP- or TNFα-mediated diseases.
PHOTOREACTION OF 4-IODOPYRIDINE WITH HETEROAROMATICS
Seki, Koh-ichi,Ohkura, Kazue,Terashima, Masanao
, p. 799 - 803 (2007/10/02)
Photoreaction of 4-iodopyridine with various heteroaromatics leads to give corresponding 4-heteroarylpyridines in appreciable yields.
ARYLATION OF HETEROCYCLES IN THE REACTION OF HETEROCYCLIC MERCURY DERIVATIVES IN THE PRESENCE OF PALLADIUM COMPLEXES
Bumagin, N. A.,Kalinovskii, I. O.,Beletskaya, I. P.
, p. 1159 - 1162 (2007/10/02)
A convenient method is proposed for the synthesis of aryl derivatives of heterocyclic compounds by the coupling reaction of heterocyclic mercury derivatives and tin derivatives with aryl and heteryl iodides in the presence of palladium complexes.In the case of organotin compounds, the reaction proceeds without the formation of side-products although mercury derivative are usually more available.
