21298-54-4

Basic information

• Product Name: Pyridine, 4-(2-thienyl)-
• CAS NO: 21298-54-4
• Molecular Formula: C9H7NS
• Molecular Weight: 161.227
• Mol File: 21298-54-4.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: Pyridine, 4-(2-thienyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Pyridine, 4-(2-thienyl)-(21298-54-4)
• EPA Substance Registry System: Pyridine, 4-(2-thienyl)-(21298-54-4)

Safety Data

• Hazardous Substances Data: 21298-54-4(Hazardous Substances Data)

Upstream product

• 188290-36-0 thiophene 
• 15854-87-2 4-iodopyridine 
• 3437-95-4 2-Iodothiophene 
• 5980-89-2 di-[2]thienyl-mercury 
• 110-86-1 pyridine 
• 17984-89-3 triethoxy(thiophen-2-yl)silane 

Downstream Products

• 27058-43-1 1-Methyl-4-(2-thienyl)-pyridiniumjodid 
• 2225176-80-5 2-p-pyridylthiophene-5-boronic acid 
• 205055-49-8 5-pyridin-4-ylthiophene-2-sulfonic acid [1-(3-cyanobenzyl)-2-oxopyrrolidin-3-(S)-yl]amide 
• 129770-69-0 5-(pyridin-4-yl) thiophene-2-carbaldehyde 

Relevant articles and documents

Synthesis and spectral properties of 5,5'-di(4-pyridyl)-2,2'-bithienyl as a new fluorescent compound

A new type of fluorescent compound, 5,5'-di(4-pyridyl)-2,2'-bithienyl, has been synthesized and its fluorescence intensity measured at 510 nm in a 40% aqueous methanol (pH3.0) with excitation at 425 nm. The quantum yield was found to be 0.52. The thienylpyridine skeleton was found for the first time as a new fluorophore.

Copper-catalyzed Hiyama coupling of (hetero)aryltriethoxysilanes with (hetero)aryl iodides

A CuI-catalyzed Hiyama coupling was achieved, which proceeds in the absence of an ancillary ligand for aryl-heteroaryl and heteroaryl-heteroaryl couplings. A P,N-ligand is required to obtain the best product yields for aryl-aryl couplings. In addition to facilitating transmetalation, CsF is also found to function as a stabilizer of the [CuAr] species, potentially generated as an intermediate after transmetalation of aryltriethoxysilanes with Cu I-catalysts in the absence of ancillary ligands.

Direct synthesis of heterobiaryls by radical addition to pyridine: Expeditious synthesis of chelating ligands

The addition of aryl radicals to pyridine may be affected in moderate yield on exposure of aryl iodides to tributyltin hydride, AIBN, and diphenyl diselenide in hot pyridine. Mixtures of ortho-, meta-, and para-aryl substituted pyridines are typically obtained. When the iodide is ortho-substituted with a hydrogen bond donor, such as o-iodophenol, significantly improved selectivity for ortho-substituted pyridines, with potential as bidentate chelating ligands, is obtained.