Bioorganic and Medicinal Chemistry Letters p. 1751 - 1756 (1998)
Update date:2022-08-05
Topics:
Page, Patrick
Barrage, Sarah
Baldock, Lorraine
Bradley, Mark
The utility of spermine, selectively functionalised and immobilised on a solid support by means of the Wang 'oxycarbonyl' linker is demonstrated by the solid-phase synthesis of a number of spermine conjugates including the natural product and potent antihypertensive agent kukoamine. The synthesis opens up the area of solid-phase spermine chemistry and library generation based on the symmetrical spermine scaffold.
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