The synthesis of symmetrical spermine conjugates using solid-phase chemistry

Article abstract of DOI:10.1016/S0960-894X(98)00303-5

The utility of spermine, selectively functionalised and immobilised on a solid support by means of the Wang 'oxycarbonyl' linker is demonstrated by the solid-phase synthesis of a number of spermine conjugates including the natural product and potent antihypertensive agent kukoamine. The synthesis opens up the area of solid-phase spermine chemistry and library generation based on the symmetrical spermine scaffold.