213133-77-8

Basic information

• Product Name: 2-(3,4-Dichlorobenzyl)-1H-benzimidazole
• Synonyms: 2-(3,4-dichlorobenzyl)1H Benzimidazole;2-(3,4-dichlorobenzyl)-1H-benzo[d]imidazole;5002 2-(3,4-DICHLOROBENZYL)-1H BENZIMIDAZOLE;2-(3,4-DICHLOROBENZYL)-1H- BENZOIMIDAZOLE;2-(3,4-Dichlorobenzyl)benzimidazole;3-BROMO-5-FLUOROPHENYLACETONE;1H-Benzimidazole,2-[(3,4-dichlorophenyl)methyl]-;2-[(3,4-dichlorophenyl)Methyl]-1H-1,3-benzodiazole
• CAS NO: 213133-77-8
• Molecular Formula: C₁₄H₁₀Cl₂N₂
• Molecular Weight: 277.15
• EINECS: 1308068-626-2
• Product Categories: API intermediates
• Mol File: 213133-77-8.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 505.6 °C at 760 mmHg
• Flash Point: 291.1 °C
• Appearance: /
• Density: 1.396 g/cm³
• Refractive Index: 1.528
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 11.60±0.10(Predicted)
• CAS DataBase Reference: 2-(3,4-Dichlorobenzyl)-1H-benzimidazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(3,4-Dichlorobenzyl)-1H-benzimidazole(213133-77-8)
• EPA Substance Registry System: 2-(3,4-Dichlorobenzyl)-1H-benzimidazole(213133-77-8)

Safety Data

• Hazardous Substances Data: 213133-77-8(Hazardous Substances Data)

Usage

Chemical Properties

White crystals

InChI:InChI=1/C9H8BrFO/c1-2-9(12)6-3-7(10)5-8(11)4-6/h3-5H,2H2,1H3

Upstream product

• 95-54-5 1,2-diamino-benzene 
• 4856-97-7 2-(Hydroxymethyl)benzimidazole 
• 95-50-1 1,2-dichloro-benzene 
• 615-43-0 2-iodophenylamine 
• 6831-55-6 2-(3,4-dichlorophenyl)acetyl chloride 
• 1004177-28-9 2-(3,4-dichlorophenyl)-N-(2-iodophenyl)acetamide 
• 5807-30-7 3,4-dichlorophenyl acetic acid 

Downstream Products

• 1602748-35-5 methyl 2-(2-(3,4-dichlorobenzyl)-1H-benzo[d]imidazol-1-yl)acetate 
• 1602747-50-1 2-(2-(3,4-dichlorobenzyl)-1H-benzo[d]imidazol-1-yl)-N-(5-isopropyl-2-methylphenyl)acetamide 
• 1602747-55-6 N-(3,5-di-tert-butylphenyl)-2-(2-(3,4-dichlorobenzyl)-1H-benzo[d]imidazol-1-yl)acetamide 
• 1047731-79-2 2-(2-(3,4-dichlorobenzyl)-1H-benzo[d]imidazol-1-yl)acetic acid 

Relevant articles and documents

Reactions of 2-carbonyl- And 2-hydroxy(or methoxy)alkylsubstituted benzimidazoles with arenes in the superacid CF3SO3H. NMR and DFT studies of dicationic electrophilic species

Reactions of 2-carbonyl- and 2-hydroxy(or methoxy)alkylbenzimidazoles with arenes in the Br?nsted superacid TfOH resulted in the formation of the corresponding Friedel-Crafts reaction products, 2-diarylmethyl and 2-arylmethyl-substituted benzimidazoles, in yields up to 90%. The reaction intermediates, protonated species derived from starting benzimidazoles in TfOH, were thoroughly studied by means of NMR and DFT calculations and plausible reaction mechanisms are discussed.

Discovery of benzimidazole derivatives as modulators of mitochondrial function: A potential treatment for Alzheimer's disease

In this study, we designed a library of compounds based on the structures of well-known ligands of the 18 kDa translocator protein (TSPO), one of the putative components of the mPTP. We performed diverse mitochondrial functional assays to assess their ability to restore cells from Aβ-induced toxicity in vitro and in vivo. Among tested compounds, compound 25 effectively improved cognitive function in animal models of AD. Given the excellent in vitro and in vivo activity and a favorable pharmacokinetic profile of compound 25, we believe that it can serve as a promising lead compound for a potential treatment option for AD.

BENZIMIDAZOLE DERIVATIVES AS MITOCHONDRIAL FUNCTION MODULATORS

Provided are a benzimidazole derivative modulating mitochondrial functions and having pharmaceutical activity as a neuro-protective agent, and a pharmaceutical composition including the compound as an active ingredient.