213134-94-2

Upstream product

• 161562-06-7 (S)-5-Azido-3-dibenzylamino-pentanenitrile 
• 213134-87-3 (3S)-5-amino-3-(N,N-dibenzylamino)pentanenitrile 
• 213134-88-4 (4S)-4-(N,N-dibenzylamino)piperidin-2-one 
• 161561-98-4 (3S)-methanesulfonic acid 4-cyano-3-(N,N-dibenzylamino)butyl ester 
• 213134-93-1 (2S,4S)-4-[[[1-benzyloxycarbonylpyrrolidine-2-carbonyl]amino]piperidin-1-yl]acetic acid ethyl ester 
• 213134-91-9 (4S)-4-(N,N-dibenzylamino-2-oxopiperidin-1-yl)acetic acid ethyl ester 
• 213134-92-0 (4S)-(4-amino-2-oxopiperidin-1-yl)acetic acid ethyl ester 

Relevant academic research and scientific papers

Enantiopure 4- and 5-Aminopiperidin-2-ones: Regiocontrolled Synthesis and Conformational Characterization as Bioactive β-Turn Mimetics

Starting from aspartic acid, we synthesized lactam-bridged β- and γ-amino acid equivalents. Using the 1,4-bis-electrophile 1b as a central intermediate, the 4- and 5-aminopiperidin-2-ones 4 and 8, respectively, were approached by regioselective functional

Homo-Freidinger lactams: Stereoselective synthesis of 4-aminopiperidin-2-one derivatives from aspartic acid

Starting from aspartic acid a stereoselective synthesis of enantiomerically pure 4-aminopiperidin-2-ones which can serve as conformationally restrained β-amino acid equivalents in peptidomimetics is described. The synthesis is based on the regioselective