21324-01-6

Upstream product

• 67-56-1 methanol 
• 56525-63-4 methyl 3-chloro-4-methyl-benzoate 
• 74-88-4 methyl iodide 
• 21312-29-8 3-iodo-4-methyl-5-nitro-benzoic acid 
• 54591-62-7 3-amino-4-methyl-5-nitrobenzoic acid 
• 21324-00-5 methyl 3-amino-5-iodo-4-methylbenzoate 

Downstream Products

• 1092307-46-4 methyl 3-amino-5-chloro-4-methylbenzoate 

Relevant academic research and scientific papers

ISOINDOLINONE COMPOUNDS

Disclosed herein is a compound or pharmaceutically acceptable salts or stereoisomers thereof of of formula I wherein X1 is linear or branched C1-6 alkyl, C3-6 cycloalkyl, -C1-6 alkyl C3-6 cycloalkyl, C6-10 aryl, 5-10 membered heteroaryl, C1-6 alkyl C6-10 aryl, C1-6 alkyl 5-10 membered heteroaryl, wherein X1 is unsubstituted or substituted with one or more of halogen, linear or branched C1-6 alkyl, linear or branched C1-6 heteroalkyl, CF3, CHF2, -O-CHF2, -O-(CH2)2-OMe, OCF3, C1-6 alkylamino, -CN, -N(H)C(O)-C1- 6alkyl, -OC(O)-C1-6alkyl, -OC(O)-C1-4alkylamino, -C(O)O-C1-6alkyl, -COOH, - CHO, -C1-6alkylC(O)OH, -C1-6alkylC(O)O-C1-6alkyl, NH2, C1-6 alkoxy or C1-6 alkylhydroxy; X2 is hydrogen, C6-10 aryl, 5-10 membered heteroaryl, -O-(5-10 membered heteroaryl), 4-8 membered heterocycloalkyl, C1-4 alkyl 4-8 membered heterocycloalkyl, -O-(4-8 membered heterocycloalkyl), -O-C1-4 alkyl-(4-8 membered heterocycloalkyl), -OC(O)-C1-4alkyl-4-8 membered heterocycloalkyl or C6 aryloxy, wherein X2 is unsubstituted or substituted with one or more of linear or branched C1-6 alkyl, NH2, NMe2 or 5-6 membered heterocycloalkyl; n is 0, 1 or 2.

GLUCOSE-SENSITIVE ALBUMIN-BINDING DERIVATIVES

This invention relates to glucose-sensitive albumin-binding diboron conjugates. More particularly the invention provides novel diboron compounds, and in particular diboronate or diboroxole compounds, useful as intermediate compounds for the synthesis of diboron conjugates. The diboron compounds are characterized by formula (I), which is: R1-X-R2, and wherein "X" is a mono- to multiatomic linker and where R1 and R2, which may be identical or different, each represents a group of Formula (lla) or (IIb) Also described are diboron conjugates represented by the general Formula (I'), which is: R1'-X'-R2', in which either the moeities R1' or R2' or X' carry a drug that is covalently attached to the diboron compound.

Pyrrolidine-amide derivative and preparation method and pharmaceutical application thereof

The invention relates to a pyrrolidine-amide derivative and a preparation method and pharmaceutical application thereof. In particular, the invention relates to a pyrrolidine-amide derivative shown in general formula (I) that is shown in the description, a preparation method of the pyrrolidine-amide derivative, a pharmaceutical composition containing the pyrrolidine-amide derivative, and application of the pharmaceutical composition as a therapeutic agent, particularly application as an XIa factor inhibitor and application in the preparation of drugs for treating and/or preventing diseases such as thromboembolism, and definitions of substituents in the general formula (I) are identical with those in the description.