Synthesis of trimethylhydroquinone derivatives as anti-allergic agents with anti-oxidative actions

DOI: 10.1248/cpb.47.177

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 177 - 181 (1999)

Update date:2022-08-03

Topics:

Authors:

Kawasaki, Nobuhide

Miyataka, Hideki

Nishiki, Mayumi

Matsumoto, Hitoshi

Inagaki, Naoki

Nagai, Hiroichi

Satoh, Toshio

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Article abstract of DOI:10.1248/cpb.47.177

A novel series of trimethylhydroquinone derivatives was synthesized and evaluated for their anti-lipid peroxidation activity in rat liver microsomes, inhibition of rat basophilic leukemia-1 (RBL-1) cell 5-lipoxygenase and 48 h homologous passive cutaneous anaphylaxis (PCA) activity in rats, 4-[4-[4- (Diphenylmethyl)-1-piperazinyl]butoxy]-2,3,6-trimethylphenol (9c) exhibited the ability to inhibit Fe³⁺-ADP induced NADPH dependent lipid peroxidation (IC₅₀=5.3x 10^-7 M), 5-lipoxygenase ((IC₅₀=3.5x10^-7 M) and PCA reaction (57% inhibition at 100 mg/kg p.o.).

Full text of DOI:10.1248/cpb.47.177

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