Chemical and Pharmaceutical Bulletin p. 177 - 181 (1999)
Update date:2022-08-03
Topics:
Kawasaki, Nobuhide
Miyataka, Hideki
Nishiki, Mayumi
Matsumoto, Hitoshi
Inagaki, Naoki
Nagai, Hiroichi
Satoh, Toshio
A novel series of trimethylhydroquinone derivatives was synthesized and evaluated for their anti-lipid peroxidation activity in rat liver microsomes, inhibition of rat basophilic leukemia-1 (RBL-1) cell 5-lipoxygenase and 48 h homologous passive cutaneous anaphylaxis (PCA) activity in rats, 4-[4-[4- (Diphenylmethyl)-1-piperazinyl]butoxy]-2,3,6-trimethylphenol (9c) exhibited the ability to inhibit Fe3+-ADP induced NADPH dependent lipid peroxidation (IC50=5.3x 10-7 M), 5-lipoxygenase ((IC50=3.5x10-7 M) and PCA reaction (57% inhibition at 100 mg/kg p.o.).
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