2133-07-5

Basic information

• Product Name: 2-(BenzylaMino)ethyl hydrogen sulfate
• Synonyms: 2-(BenzylaMino)ethyl hydrogen sulfate;Sulfuric acid mono-(2-benzylamino-ethyl) ester;2-(BENZYLAMINO)ETHYL HYDROGEN SULFATE(WXC04947)
• CAS NO: 2133-07-5
• Molecular Formula: C₉H₁₃NO₄S
• Molecular Weight: 231.26882
• Mol File: 2133-07-5.mol
• Article Data: 6

Chemical Properties

• Melting Point: 230-231 °C
• Appearance: /
• Density: 1.340±0.06 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: -3.86±0.18(Predicted)
• CAS DataBase Reference: 2-(BenzylaMino)ethyl hydrogen sulfate(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(BenzylaMino)ethyl hydrogen sulfate(2133-07-5)
• EPA Substance Registry System: 2-(BenzylaMino)ethyl hydrogen sulfate(2133-07-5)

Safety Data

• Hazardous Substances Data: 2133-07-5(Hazardous Substances Data)

Usage

Sulfate salt

of benzylamine and ethylamine

Organic compounds

containing amine functional groups

Common use

as a reactant in organic synthesis

Application

in the production of pharmaceuticals and other fine chemicals

Role

as a catalyst in certain chemical reactions

Physical form

colorless, crystalline solid

Solubility

soluble in water and polar organic solvents

Safety precautions

potential for skin and eye irritation

Upstream product

• 104-63-2 N-Benzylethanolamine 
• 1072-53-3 ethyleneglycol sulfate 
• 100-46-9 benzylamine 

Downstream Products

• 3484-99-9 3-benzyl-1,3-thiazolidine-2-thione 
• 205242-66-6 (2S)-4-(phenylmethyl)-2-{[(phenylmethyl)oxy]methyl}morpholine 
• 1074-42-6 1-benzylaziridine 
• 1403506-15-9 (S)-1-benzyl-2-phenoxymethylmorpholine 

Relevant articles and documents

Modular One-Step Three-Component Synthesis of Tetrahydroisoquinolines Using a Catellani Strategy

Reported is a modular one-step three-component synthesis of tetrahydroisoquinolines using a Catellani strategy. This process exploits aziridines as the alkylating reagents, through palladium/norbornene cooperative catalysis, to enable a Catellani/Heck/aza-Michael addition cascade. This mild, chemoselective, and scalable protocol has broad substrate scope (43 examples, up to 90 % yield). The most striking feature of this protocol is the excellent regioselectivity and diastereoselectivity observed for 2-alkyl- and 2-aryl-substituted aziridines to access 1,3-cis-substituted and 1,4-cis-substituted tetrahydroisoquinolines, respectively. Moreover, this is a versatile process with high step and atom economy.

Observations on the modified wenker synthesis of aziridines and the development of a biphasic system

A cheap and reliable process for the modified Wenker cyclization to afford aziridines has been achieved using biphasic conditions for a range of amino alcohol starting materials. A 100 mmol "one-pot" process has also been devised, and the enantiopurity of the starting amino alcohol is retained in the aziridine product.

METHODS OF USE FOR INHIBITORS OF AKT ACTIVITY

Invented is the use of 1 H-imidazo[4,5-c]pyridin-2-yl compounds in the treatment of specified cancers.