2133-07-5

Usage

Sulfate salt

of benzylamine and ethylamine

Organic compounds

containing amine functional groups

Common use

as a reactant in organic synthesis

Application

in the production of pharmaceuticals and other fine chemicals

Role

as a catalyst in certain chemical reactions

Physical form

colorless, crystalline solid

Solubility

soluble in water and polar organic solvents

Safety precautions

potential for skin and eye irritation

Upstream product

• 1072-53-3 ethyleneglycol sulfate 
• 100-46-9 benzylamine 
• 104-63-2 N-Benzylethanolamine 

Downstream Products

• 3484-99-9 3-benzyl-1,3-thiazolidine-2-thione 
• 1403506-15-9 (S)-1-benzyl-2-phenoxymethylmorpholine 
• 1074-42-6 1-benzylaziridine 
• 205242-66-6 (2S)-4-(phenylmethyl)-2-{[(phenylmethyl)oxy]methyl}morpholine 

Relevant academic research and scientific papers

Modular One-Step Three-Component Synthesis of Tetrahydroisoquinolines Using a Catellani Strategy

Reported is a modular one-step three-component synthesis of tetrahydroisoquinolines using a Catellani strategy. This process exploits aziridines as the alkylating reagents, through palladium/norbornene cooperative catalysis, to enable a Catellani/Heck/aza-Michael addition cascade. This mild, chemoselective, and scalable protocol has broad substrate scope (43 examples, up to 90 % yield). The most striking feature of this protocol is the excellent regioselectivity and diastereoselectivity observed for 2-alkyl- and 2-aryl-substituted aziridines to access 1,3-cis-substituted and 1,4-cis-substituted tetrahydroisoquinolines, respectively. Moreover, this is a versatile process with high step and atom economy.

Practical asymmetric synthesis of an edivoxetine·HCl intermediate via an efficient diazotization process

A convergent synthesis of (S)-(4-benzylmorpholin-2-yl)(morpholino)methanone methanesulfonate (1), a key regulatory starting material for edivoxetine·HCl, was developed at Eli Lilly & Company. This novel synthesis utilizes d-serine as the source of chirali

Observations on the modified wenker synthesis of aziridines and the development of a biphasic system

A cheap and reliable process for the modified Wenker cyclization to afford aziridines has been achieved using biphasic conditions for a range of amino alcohol starting materials. A 100 mmol "one-pot" process has also been devised, and the enantiopurity of the starting amino alcohol is retained in the aziridine product.

A PROCESS FOR THE PREPARATION OF MORPHOLINO SULFONYL INDOLE DERIVATIVES

The present invention relates to a process for the preparation of the compounds of formula (I) which are morpholino sulphonyl indole derivatives. The compounds of formula (I) are capable of inhibiting, modulating or regulating Insulin-Like-Growth Factor I

METHODS OF USE FOR INHIBITORS OF AKT ACTIVITY

Invented is the use of 1 H-imidazo[4,5-c]pyridin-2-yl compounds in the treatment of specified cancers.

INHIBITORS OF AKT ACTIVITY

Invented are novel 1 H-imidazo[4,5-c]pyridin-2-yl compounds, the use of such compounds as inhibitors of protein kinase B activity and in the treatment of cancer and arthritis.