3484-99-9Relevant academic research and scientific papers
Synthesis method and application of 3-benzyl-1,3-thiazolidine-2-thione
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Paragraph 0056; 0057; 0071; 0076; 0077; 0082, (2018/04/03)
The invention provides a synthesis method of 3-benzyl-1,3-thiazolidine-2-thione. The synthesis method comprises the following step of performing reaction on 1,3-thiazolidine-2-thione, an alkaline reagent and benzyl halide in a solvent to obtain the 3-benzyl-1,3-thiazolidine-2-thione. According to the synthesis method, an optimization condition of synthesizing the 3-benzyl-1,3-thiazolidine-2-thionethrough exploration, the yield of the 3-benzyl-1,3-thiazolidine-2-thione is 67.8 percent, and the purity reaches up to 99.99 percent. Further, when the 3-benzyl-1,3-thiazolidine-2-thione is synthesized with the method provided by the invention, 2-benzylthio-1,3-thiazolidine as an isomer can also be produced, and the two compounds both have higher activity in a herbicide and an insecticide. In addition, the invention also provides application of the 3-benzyl-1,3-thiazolidine-2-thione in the herbicide and the insecticide.
New silver complexes with mixed thiazolidine and phosphine ligands as highly potent antimalarial and anticancer agents
Mohd Sofyan, Nur Rahimah Fitrah,Nordin, Fariza Juliana,Mohd Abd Razak, Mohd Ridzuan,Abdul Halim, Syahrina Nur 'Ain,Mohd Khir, Nur Adila Fatin,Muhammad, Amirrudin,Rajab, Nor Fadilah,Sarip, Rozie
, (2018/08/10)
Five silver(I) complexes containing a mixed ligand system of phosphine and thiazolidine were successfully synthesized. The structural information of the complexes was assembled using various spectroscopic techniques such as CHN elemental analysis, Fourier
Reaction of 2-thiazolidinethione with halohydrocarbon: Synthesis of novel N-alkylated 2-thiazolidinethione and S-alkylated thiazoline derivatives
Liu, Yufa,Liu, Junwei,Liu, Xiuming
experimental part, p. 275 - 278 (2011/06/10)
Reaction of 2-thiazolidinethione with halohydrocarbon in ethanol gave a series of N-alkylated 2-thiazolidinethione and S-alkylated thiazoline derivatives in excellent yields. The reaction was carried out under mild conditions using NaOH as a base and it did not require protection from air.
Unexpected orthogonality of S-benzoxazolyl and S-thiazolinyl glycosides: Application to expeditious oligosaccharide assembly
Kaeothip, Sophon,Pornsuriyasak, Papapida,Rath, Nigam P.,Demchenko, Alexei V.
supporting information; experimental part, p. 799 - 802 (2009/09/05)
Thorough mechanistic studies of the alkylation pathway for the activation of glycosyl thioimidates have led to the development of the " thioimidateonly orthogonal strategy". Discrimination among S-thiazolinyl (STaz) and S-benzoxazolyl (SBox) anomeric leav
Synthesis and biological evaluation of thiazolidine-2-one 1,1-dioxide as inhibitors of Escherichia coli β-ketoacyl-ACP-synthase III (FabH)
Alhamadsheh, Mamoun M.,Waters, Norman C.,Huddler, Donald P.,Kreishman-Deitrick, Mara,Florova, Galina,Reynolds, Kevin A.
, p. 879 - 883 (2007/10/03)
A series of cyclic sulfones has been synthesized and their activity against β-ketoacyl-ACP-synthase III (FabH) has been investigated. The compounds are selectively active against Escherichia coli FabH (ecFabH), but not Mycobacterium tuberculosis FabH (mtFabH) or Plasmodium falciparum KASIII (PfKASIII). The activity against ecFabH ranges from 0.9 to >100 μM and follows a consistent general SAR trend. Many of the compounds were shown to have antimalarial activity against chloroquine (CQ)-sensitive (D6) P. falciparum (IC50 = 5.3 μM for the most potent inhibitor) and some were active against E. coli (MIC = 6.6 μg/ml for the most potent inhibitor).
Dopamine-beta-hydroxylase inhibitors
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, (2008/06/13)
Dopamine-β-hydroxylase inhibitors of structure: Pharmaceutical compositions containing them and their use in methods of lowering blood pressure in mammals.
