213313-13-4Relevant academic research and scientific papers
Asymmetric synthesis of antimitotic combretadioxolane with potent antitumor activity against multi-drug resistant cells
Shirai, Ryuichi,Takayama, Hisae,Nishikawa, Asuka,Koiso, Yukiko,Hashimoto, Yuichi
, p. 1997 - 2000 (2007/10/03)
The (S,S)-enantiomer of combretadioxolane (3), designed as a chirally preorganized derivative of combretastatin A-4, exhibited quite strong tubulin polymerization-inhibitory activity (IC50: 4-6 μM). (S,S)-3 is 20 times more potent than vincristine as an in vitro growth inhibitor (in terms of GI50) of the multi-drug-resistant (MDR) cell line PC-12, which produces P- glycoprotein.
