213313-12-3

Upstream product

• 5779-98-6 O-methoxymethylisovanillin 
• 134029-74-6 [(3,4,5-trimethoxyphenyl)methyl]phosphoric acid diethyl ester 

Downstream Products

• 213313-14-5 (4S,5S)-4-(4-Methoxy-3-methoxymethoxy-phenyl)-5-(3,4,5-trimethoxy-phenyl)-[1,3]dioxolane 
• 213313-09-8 (1R,2R)-1-(4-Methoxy-3-methoxymethoxy-phenyl)-2-(3,4,5-trimethoxy-phenyl)-ethane-1,2-diol 
• 213313-13-4 (1S,2S)-1-(4-Methoxy-3-methoxymethoxy-phenyl)-2-(3,4,5-trimethoxy-phenyl)-ethane-1,2-diol 

Relevant academic research and scientific papers

Asymmetric synthesis of antimitotic combretadioxolane with potent antitumor activity against multi-drug resistant cells

The (S,S)-enantiomer of combretadioxolane (3), designed as a chirally preorganized derivative of combretastatin A-4, exhibited quite strong tubulin polymerization-inhibitory activity (IC50: 4-6 μM). (S,S)-3 is 20 times more potent than vincristine as an in vitro growth inhibitor (in terms of GI50) of the multi-drug-resistant (MDR) cell line PC-12, which produces P- glycoprotein.