213331-74-9

Upstream product

• 118358-66-0 N-(9-fluorenylmethyloxycarbonyl)-L-serine benzyl ester 
• 213331-70-5 2,2,2-Trichloro-acetimidic acid (3aR,4R,6R,7R,7aR)-7-azido-2,2-dimethyl-4-triisopropylsilanyloxymethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyran-6-yl ester 
• 213331-72-7 2,2,2-Trichloro-acetimidic acid (3aR,4R,6S,7R,7aR)-7-azido-2,2-dimethyl-4-triisopropylsilanyloxymethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyran-6-yl ester 

Downstream Products

• 213331-78-3 (S)-3-((3aR,4R,6S,7R,7aR)-7-Azido-4-hydroxymethyl-2,2-dimethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyran-6-yloxy)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-propionic acid benzyl ester 
• 100929-06-4 (S)-2-Amino-3-((2S,3R,4R,5R,6R)-4,5-diacetoxy-6-acetoxymethyl-3-acetylamino-tetrahydro-pyran-2-yloxy)-propionic acid benzyl ester 
• 100929-03-1 benzyl O-(2-acetamido-3,4,6-tri-O-acetyl-2-deoxy-α-D-galactopyranosyl)-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-serinate 
• 100929-00-8 benzyl O-(3,4,6-tri-O-acetyl-2-azido-2-deoxy-α-D-galactopyranosyl)-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-serinate 
• 120173-57-1 N-(9-fluorenylmethoxycarbonyl)-O-(3,4,6-tri-O-acetyl-2-acetamido-2-deoxy-α-D-galactopyranosyl)-L-serine 
• 218291-42-0 (S)-3-[(2S,3R,4R,5R,6R)-3-Azido-6-(tert-butyl-dimethyl-silanyloxymethyl)-4,5-dihydroxy-tetrahydro-pyran-2-yloxy]-2-(9H-fluoren-9-ylmethoxycarbonylamino)-propionic acid benzyl ester 
• 218291-44-2 C₅₆H₆₆N₄O₂₃ 
• 213332-03-7 C₅₉H₇₁N₃O₂₆ 
• 213331-80-7 C₆₂H₇₅N₃O₂₆ 
• 213332-04-8 C₆₃H₇₅N₃O₂₈ 

Relevant academic research and scientific papers

Hydroxynorleucine as a glycosyl acceptor is an efficient means for introducing amino acid functionality into complex carbohydrates

A new approach to the synthesis of biologically relevant glycosyl amino acids using a non-natural amino acid as the glycosyl acceptor is described. The procedure involves a glycosylation reaction of a suitable carbohydrate donor with Fmoc-L-hydroxynorleucine benzyl ester. This reaction results in the direct incorporation of the amino acid moiety. The acceptor can be used for the preparation of α- or β-O-linked glycosides depending upon the nature of the glycosyl donor. This method has been applied in the synthesis of six different tumor-associated carbohydrate antigens.

Exploration of modalities in building α-O-linked systems through glycal assembly: A total synthesis of the mucin-related F1α antigen

The total synthesis of the F1α antigen, a member of the tumor- associated O-linked mucin glycopeptides, was achieved via two alternative routes. In the first approach, an α-O-linkage between serine/threonine and Ga1NAc (2-deoxy-2-N-acetylamino-D-galactose