Xylylated dimers of putrescine and polyamines: Influence of the polyamine backbone on spermidine transport inhibition

Article abstract of DOI:10.1016/S0960-894X(03)00668-1

Dimeric norspermidine and spermidine derivatives are strong competitive inhibitors of polyamine transport. A xylyl tether was used for the dimerization of various triamines and spermine via a secondary amino group, and of putrescine via an ether or an amino group. Dimerization of putrescine moieties potentiates their ability to compete against spermidine transport to a much greater extent than for triamine dimers.