21344-98-9

Basic information

• Product Name: 4-(4-methoxyphenyl)-N-phenyl-1,3-thiazol-2-amine
• Synonyms: 4-(4-methoxyphenyl)-N-phenyl-1,3-thiazol-2-amine
• CAS NO: 21344-98-9
• Molecular Weight: 282.366
• Mol File: 21344-98-9.mol
• Article Data: 16

Chemical Properties

• CAS DataBase Reference: 4-(4-methoxyphenyl)-N-phenyl-1,3-thiazol-2-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-methoxyphenyl)-N-phenyl-1,3-thiazol-2-amine(21344-98-9)
• EPA Substance Registry System: 4-(4-methoxyphenyl)-N-phenyl-1,3-thiazol-2-amine(21344-98-9)

Safety Data

• Hazardous Substances Data: 21344-98-9(Hazardous Substances Data)

Upstream product

• 43009-16-1 phenyldithiocarbamic acid triethylamine salt 
• 100-06-1 1-(4-methoxyphenyl)ethanone 
• 103-85-5 monophenylthiourea 
• 2632-13-5 2-Bromo-4'-methoxyacetophenone 
• 93435-57-5 α-tosyloxy-p-methoxyacetophenone 
• 915288-76-5 1-(1-azido-2-iodoethyl)-4-methoxybenzene 
• 103-72-0 phenyl isothiocyanate 
• 18418-42-3 phenyl-dithiocarbamic acid; sodium salt 
• 51034-34-5 potassium aniline dithiocarbamate 
• 1226922-89-9 C₅H₅N*C₇H₇NS₂ 
• 96155-57-6 1-(4-methoxyphenyl)ethanone O-acetyl oxime 

Relevant articles and documents

Visible light triggered, catalyst free approach for the synthesis of thiazoles and imidazo[2,1-: B] thiazoles in EtOH:H2O green medium

The development of a visible light promoted, mild and greener approach for the synthesis of highly functionalized thiazoles and imidazo[2,1-b]thiazoles under photochemical activation in EtOH:H2O green medium is demonstrated. The characteristic feature of the present protocol is the utilization of visible light (an omnipresent, nontoxic, environmentally benign and inexpensive reagent) to form C-S and C-N bonds and circumvent the use of catalysts or photosensitizers. The reported protocol is the first example of visible light promoted synthesis of thiazoles and imidazo[2,1-b]thiazoles with various attractive features like being catalyst free, eco-efficient and possessing cost effectiveness, short reaction time, excellent yields and sustainability to fulfill the parameters of green chemistry.

CuBr2 mediated synthesis of 2-Aminothiazoles from dithiocarbamic acid salts and ketones

In a one-pot procedure, CuBr2 has been used as a efficient desulfurizing agent in the synthesis of 2-aminothiazoles by the condensation of in situ-generated 1-substituted thioureas from their dithiocarbamic acid salts, with in situ-generated α-bromoketones from ketones. All reactions were carried out under optimized reaction conditions and gave the target products in 61–95% yield.

Copper-Catalyzed Coupling of Oxime Acetates with Isothiocyanates: A Strategy for 2-Aminothiazoles

A new strategy for 2-aminothiazoles is developed via the copper-catalyzed coupling of oxime acetates with isothiocyanates. Various 4-substituted and 4,5-disubstituted 2-aminothiazoles were formed smoothly under mild reaction conditions. This process involved copper-catalyzed N-O bond cleavage, activation of vinyl sp2 C-H bonds, and C-S/C-N bond formations. It is noteworthy that the oxime acetates were used not only as a substrate but also as a single oxidant.