213474-87-4Relevant academic research and scientific papers
A facile synthesis and some new reactions of N-benzylcarboxamides with essential amino acids
El-Sayed, Ragab A.
, p. 207 - 213 (2007/10/03)
N-Benzyl-p-chloro and N-Benzyl-2,4-dichlorobenzamide react with hlorosulfonic acid to give the corresponding p-sulfonyl chlorides (1,19), which condensed with nucleophiles to give amino acid derivatives (2-7) and (20-25). Some of the corresponding methyl esters (8-11) were prepared. Hydrazinolysis of these methyl esters yielded the hydrazides (12-15). Coupling reactions of some amino acid derivatives with amino acid methyl ester hydrochloride in THF-Et3N medium using the dicyclohexylcarbodiimide method furnishes the desired dipeptide methyl esters (16-18, 26-28). Some spectral data are briefly discussed.
