213487-41-3

Upstream product

• 88121-25-9 9-[3′,5′-O-(1,1,3,3-tetraisopropyldisiloxyl)-2′-O-trifluormethylsulfonyl-β-D-arabinofuranosyl]adenine 
• 88121-26-0 2'?azido?2'?deoxy?3',5'?O?(1,1,3,3?tetraisopropyldisiloxane?1,3?diyl)adenosine 
• 88091-68-3 2-(4-nitrophenyl)ethoxycarbonyl chloride 
• 160056-49-5 2'-amino-2'-deoxy-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-adenosine 

Downstream Products

• 213487-51-5 Succinic acid mono-((2R,3S,4R,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-[2-(4-nitro-phenyl)-ethoxycarbonylamino]-5-{6-[2-(4-nitro-phenyl)-ethoxycarbonylamino]-purin-9-yl}-tetrahydro-furan-3-yl) ester 
• 213487-44-6 (9-{(2R,3R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-3-[2-(4-nitro-phenyl)-ethoxycarbonylamino]-tetrahydro-furan-2-yl}-9H-purin-6-yl)-carbamic acid 2-(4-nitro-phenyl)-ethyl ester 
• 213487-43-5 (9-{(2R,3R,4S,5R)-4-Hydroxy-5-hydroxymethyl-3-[2-(4-nitro-phenyl)-ethoxycarbonylamino]-tetrahydro-furan-2-yl}-9H-purin-6-yl)-carbamic acid 2-(4-nitro-phenyl)-ethyl ester 

Relevant academic research and scientific papers

Synthesis of Phosphoramidite Building Blocks of 2′-Amino-2′-deoxyribonucleosides: New Compounds for Oligonucleotide Synthesis

The chemical synthesis of 2′-amino-2′-deoxyribonucleosides of uracil, cytosine, adenine, and guanine, and their conversion into suitably protected 3′-phosphoramidite building blocks 35-40 for oligonucleotide synthesis are described. The aglycone and the 2′-amino functions were protected using the 2-(4-nitrophenyl)ethoxycarbonyl (npeoc) group. The synthesis of the 3′-?-succinyl (3′-?-(3-carboxypropanoyl))-substituted starting nucleoside 41 is described and its behavior examined in solution and on solid phase with regard to an anticipated migration during 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) deprotection. Oligonucleotides were prepared using the new building blocks, and their hybridization properties were studied by UV-melting techniques.