213532-97-9

Upstream product

• 58479-61-1 tert-butylchlorodiphenylsilane 
• 213532-96-8 (S)-5,6-Dihydroxy-hexanoic acid 4-methoxy-benzyl ester 
• 187851-95-2 (4-methoxyphenyl)methyl hex-5-enoate 

Downstream Products

• 213532-99-1 (R)-5-Azido-6-(tert-butyl-diphenyl-silanyloxy)-hexanoic acid 4-methoxy-benzyl ester 
• 209257-74-9 (6R)-6-[(tert-butyldiphenylsilyl)oxymethyl]piperidin-2-one 
• 213532-95-7 (R)-6-hydroxymethyl-piperidin-2-one 
• 213532-98-0 (S)-6-(tert-Butyl-diphenyl-silanyloxy)-5-methanesulfonyloxy-hexanoic acid 4-methoxy-benzyl ester 

Relevant academic research and scientific papers

Practical asymmetric synthesis of both enantiomers of 6-(hydroxymethyl)piperidin-2-one

A practical asymmetric synthesis of both enantiomers of 6 (hydroxymethyl)piperidin-2-one 1 is described. Asymmetric dihydroxylation (AD) of alkenyl ester 2 using the (DHQ)2AQN ligand provides diol (5S)-3 in ≤95% ee after recrystallisation. This diol can subsequently be transformed into (6R)-1 using a five step reaction sequence. By employing (DHQD)2AQN [1,4-bis(dihydroquininyl)anthraquinone] in the initial AD reaction, (6S)-1 can be prepared in an analogous fashion.