213532-95-7

Basic information

• Product Name: (6R)-6-(HYDROXYMETHYL)-2-PIPERIDINONE
• Synonyms: (R)-6-(Hydroxymethyl)-2-piperidinone;(R)-6-(HydroxyMethyl)piperidin-2-one;2-Piperidinone, 6-(hydroxymethyl)-, (6R)-;(6R)-6-(HYDROXYMETHYL)-2-PIPERIDINONE
• CAS NO: 213532-95-7
• Molecular Formula: C₆H₁₁NO₂
• Molecular Weight: 129.15704
• EINECS: -0
• Mol File: 213532-95-7.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 346℃
• Flash Point: 163℃
• Appearance: /
• Density: 1.098
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: (6R)-6-(HYDROXYMETHYL)-2-PIPERIDINONE(CAS DataBase Reference)
• NIST Chemistry Reference: (6R)-6-(HYDROXYMETHYL)-2-PIPERIDINONE(213532-95-7)
• EPA Substance Registry System: (6R)-6-(HYDROXYMETHYL)-2-PIPERIDINONE(213532-95-7)

Safety Data

• Hazardous Substances Data: 213532-95-7(Hazardous Substances Data)

Usage

General Description

(6R)-6-(Hydroxymethyl)-2-piperidinone is a chemical compound with the molecular formula C6H11NO2. It is a cyclic amino alcohol with a piperidinone core structure. (6R)-6-(HYDROXYMETHYL)-2-PIPERIDINONE is commonly used as a building block in the synthesis of various pharmaceuticals and organic compounds. The hydroxymethyl group at the 6-position of the piperidinone ring makes it a versatile precursor for the preparation of different derivatives. It is also used as a chiral building block in the synthesis of certain drugs due to its specific stereochemistry. Additionally, (6R)-6-(Hydroxymethyl)-2-piperidinone has been explored for its potential biological properties and has found applications in various fields of chemical research and drug development.

Upstream product

• 213532-99-1 (R)-5-Azido-6-(tert-butyl-diphenyl-silanyloxy)-hexanoic acid 4-methoxy-benzyl ester 
• 213532-97-9 (S)-6-(tert-Butyl-diphenyl-silanyloxy)-5-hydroxy-hexanoic acid 4-methoxy-benzyl ester 
• 213532-96-8 (S)-5,6-Dihydroxy-hexanoic acid 4-methoxy-benzyl ester 
• 187851-95-2 (4-methoxyphenyl)methyl hex-5-enoate 
• 72002-30-3 (R)-6-oxo-piperidine-2-carboxylic acid 
• 7620-28-2 D-2-aminoadipic acid 
• 183890-34-8 methyl (R)-6-oxopiperidine-2-carboxylate 
• 209257-74-9 (6R)-6-[(tert-butyldiphenylsilyl)oxymethyl]piperidin-2-one 

Relevant articles and documents

Lactams as prostanoid receptor ligands. Part 4: 2-Piperidones as selective EP4 receptor agonists

2-Piperidones were prepared bearing heptanoic acid or a thioether heptanoic acid at the 1-position as well as appropriately substituted at the 6-position to mimic the structure of prostaglandins. The stereochemical purity at the 6-position was determined to be ≥95% ee for an advanced synthetic intermediate. The 2-piperidones were identified as potent agonists at the EP4 prostanoid receptor. They displayed a high affinity (K i 5-130 nM) at EP4 and subtype selectivity.

EP4 receptor agonist, compositions and methods thereof

This invention relates to potent selective agonists of the EP4 subtype of prostaglandin E2 receptors, their use or a formulation thereof in the treatment of glaucoma and other conditions, which are related to elevated intraocular pressure in the eye of a patient. This invention further relates to the use of the compounds of this invention for mediating the bone modeling and remodeling processes of the osteoblasts and osteoclasts.