213546-35-1

Upstream product

• 3443-45-6 1-pyrenebutyric acid 
• 172271-62-4 tert-Butoxycarbonylamino-acetic acid (1aR,1bS,4aR,7aS,7bS,8R,9R,9aS)-4a,7b,9-trihydroxy-1,1,6,8-tetramethyl-5-oxo-3-trityloxymethyl-1,1a,1b,4,4a,5,7a,7b,8,9-decahydro-cyclopropa[3,4]benzo[1,2-e]azulen-9a-yl ester 
• 76-83-5 trityl chloride 
• 17673-25-5 phorbol 
• 82400-03-1 phorbol-20-trityl ether 
• 4530-20-5 BOC-glycine 

Relevant academic research and scientific papers

Photoaffinity labeling of PKC isozymes by phorbol ester derivatives

Photoaffinity probes PPDA and PPTD, which have diazoacetyl and trifluorodiazopropionyl group at C-13 position in phorbol, respectively, were synthesized. Photoaffinity labeling of protein kinase C isozymes by both the probes resulted in specific cross-linking. Copyright (C) 1998 Elsevier Science Ltd.

Photoaffinity labeling of PKC with a phorbol derivative: Importance of the 13-acyl group in phorbol ester-PKC interaction

We report the design and synthesis of a novel photoaffinity ligand, phorbol 12-(1-pyrenebutyrate) 13-diazoacetate (PPDA, 6). This photolabile phorbol derivative labeled with tritium was used for photocrosslinking experiments with a sample of PKC partially purified from rat brain, and specific binding of 6 to PKC was observed.