172271-62-4

Upstream product

• 4530-20-5 BOC-glycine 
• 82400-03-1 phorbol-20-trityl ether 
• 76-83-5 trityl chloride 
• 17673-25-5 phorbol 

Downstream Products

• 213546-35-1 4-Pyren-1-yl-butyric acid (1aR,1bS,4aR,7aS,7bS,8R,9R,9aS)-9a-(2-tert-butoxycarbonylamino-acetoxy)-4a,7b-dihydroxy-1,1,6,8-tetramethyl-5-oxo-3-trityloxymethyl-1a,1b,4,4a,5,7a,7b,8,9,9a-decahydro-1H-cyclopropa[3,4]benzo[1,2-e]azulen-9-yl ester 

Relevant academic research and scientific papers

Synthesis and characterization of new photolabile phorbol esters for affinity labeling of protein kinase C

Three new photolabile phorbol esters (3, 6, and 9) with a diazoacetyl group at positions 3, 12, and 13, respectively, have been synthesized from phorbol (1a) and found to bind with significant affinity to the peptide (peptide C) incorporating the phorbol

Photoaffinity labeling of PKC with a phorbol derivative: Importance of the 13-acyl group in phorbol ester-PKC interaction

We report the design and synthesis of a novel photoaffinity ligand, phorbol 12-(1-pyrenebutyrate) 13-diazoacetate (PPDA, 6). This photolabile phorbol derivative labeled with tritium was used for photocrosslinking experiments with a sample of PKC partially purified from rat brain, and specific binding of 6 to PKC was observed.

Photoaffinity labeling of PKC isozymes by phorbol ester derivatives

Photoaffinity probes PPDA and PPTD, which have diazoacetyl and trifluorodiazopropionyl group at C-13 position in phorbol, respectively, were synthesized. Photoaffinity labeling of protein kinase C isozymes by both the probes resulted in specific cross-linking. Copyright (C) 1998 Elsevier Science Ltd.