21355-97-5Relevant academic research and scientific papers
Design, synthesis, anticancer activity, molecular docking and ADME studies of novel methylsulfonyl indole-benzimidazoles in comparison with ethylsulfonyl counterparts
Karadayi, Fikriye Zengin,Yaman, Murat,Kisla, Mehmet Murat,Konu, Ozlen,Ates-Alagoz, Zeynep
, p. 9010 - 9019 (2021/06/06)
Cancer poses a world-wide healthcare problem, demanding selective and effective therapy protocols. To address that, a vast amount of therapeutic candidates are being investigated in the field of medicinal chemistry. Accordingly, indole-benzimidazole structures have recently gained considerable interest because of their anticancer properties and estrogen receptor (ER) modulatory actions. In this study, novel methylsulfonyl indole-benzimidazole derivatives have been synthesized upon substitution of respectively the first (R1) and fifth (R2) positions of benzimidazole and indole groups. Structure and activity relationships were then studied via1H NMR, 13C NMR, mass spectral and in silico docking analyses, as well as cell viability measurements. We found that the compounds exhibited substantial affinity levels towards ER alpha (ERα). In addition, the correlation analysis of cytotoxicity profiles between ethyl- and methyl-sulfonyl indole-benzimidazoles revealed a collection of effective and consistent R1 and R2 substitutions. However, for some candidate derivatives, distinctive cytotoxicity levels and varying viability versus ERα affinity correlations were observable across the studies, suggesting that the sulfonyl side chain modifications themselves can also influence the ERα binding levels. These results demonstrated that our novel methylsulfonyl indole-benzimidazole derivatives, similar to their ethylsulfonyl counterparts, exhibit anticancer effects with potential estrogen receptor modulatory actions. This journal is
REACTION OF 2,4-DISUBSTITUTED CHLOROBENZENES WITH 3-ALKYLAMINO- AND 3-DIALKYLAMINOPROPIONITRILES
Plakidin, Val. L.,Vostrova, V. N.
, p. 295 - 303 (2007/10/02)
The reaction of 2,4-disubstituted chlorobenzenes with 3-dialkylaminopropionitriles at 65-170 deg C leads to the formation of 2,4-disubstituted N,N-dialkylanilines, and the reaction with 3-alkylaminopropionitriles at 20-130 deg C leads to the formation of 2,4-disubstituted N-alkyl-N-β-cyanoethylanilines.In addition, in the latter case at high temperature (130 deg C) the cyanoethyl group is removed from the substituted N-alkyl-N-β-cyanoethylaniline with the formation of the 2,4-disubstituted N-alkylaniline.
