213552-29-5Relevant academic research and scientific papers
Efficient desilylation of some nucleoside derivatives with potassium tert-butoxide in dimethylformamide
Negron,Vasquez,Calderon,Cruz,Gavino,Islas
, p. 3021 - 3027 (1998)
A new method for deprotecting silyl ethers of nucleosides has been established by using potassium tert-butoxide in dimethylformamide at room temperature.
Synthesis and solution conformation studies of 3-substituted uridine and pseudouridine derivatives
Chang, Yu-Cheng,Herath, Jayatilake,Wang, Tony H.-H.,Chow, Christine S.
, p. 2676 - 2686 (2008/09/21)
A series of 3-substituted uridine and pseudouridine derivatives, based on the naturally occurring 3-(3-amino-3-carboxypropyl) modification, were synthesized. Their aqueous solution conformations were determined by using circular dichroism and NMR spectroscopy. Functional group composition and chain length were shown to have only a subtle influence on the distribution of syn/anti conformations of the modified nucleosides. The dominating factor appears to be the glycosidic linkage (C- vs. N-glycoside) in determining the nucleoside conformation.
Efficient synthesis of 5-hydroxymethyl pyrimidines and their nucleosides using microwave irradiation
Abdel-Rahman, Adel A.-H.,El Ashry, El Sayed H.
, p. 2043 - 2044 (2007/10/03)
Hydroxymethylation of uracil (1), cytosine (3), 5-hydroxymethyl-2′,3′-O-isopropylideneuridine (5), 5′-O-tert-butyldiphenylsilyl-2′,3′-O-isopropylideneuridine (7), 2′,3′-O-isopropylidenecytidine (9) and 2′,3′-O-isopropylidene-5′-O-tritylcytidine (11) was efficiently carried out with paraformaldehyde in alkaline medium under microwave irradiation in very high yield.
