213744-81-1

Basic information

• Product Name: 4-chloro-5-iodo-7-isopropyl-7H-pyrrolo[2,3-d]pyrimidine
• Synonyms: 4-chloro-5-iodo-7-isopropyl-7H-pyrrolo[2,3-d]pyrimidine;7H-Pyrrolo[2,3-d]pyrimidine, 4-chloro-5-iodo-7-(1-methylethyl)-;4-Chloro-5-Iodo-7-Isopropyl-7H-Pyrrolo[2,3-D]Pyrimidine(WX636135)
• CAS NO: 213744-81-1
• Molecular Formula: C₉H₉ClIN₃
• Molecular Weight: 321.54533
• Mol File: 213744-81-1.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 382.7±37.0 °C(Predicted)
• Appearance: /
• Density: 1.93±0.1 g/cm3(Predicted)
• PKA: 2.50±0.30(Predicted)
• CAS DataBase Reference: 4-chloro-5-iodo-7-isopropyl-7H-pyrrolo[2,3-d]pyrimidine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-chloro-5-iodo-7-isopropyl-7H-pyrrolo[2,3-d]pyrimidine(213744-81-1)
• EPA Substance Registry System: 4-chloro-5-iodo-7-isopropyl-7H-pyrrolo[2,3-d]pyrimidine(213744-81-1)

Safety Data

• Hazardous Substances Data: 213744-81-1(Hazardous Substances Data)

Upstream product

• 123148-78-7 4-chloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidine 
• 67-63-0 isopropyl alcohol 
• 3680-69-1 4-chloro-1H-pyrrolo[2,3-d]pyrimidine 
• 75-30-9 2-iodo-propane 
• 75-26-3 isopropyl bromide 

Downstream Products

• 833481-43-9 3-(4-chloro-7-isopropyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-5-methylphenol 

Relevant articles and documents

SUBSTITUTED PYRROLO[2,3-D]PYRIMIDINES COMPOUNDS AS RET KINASE INHIBITORS

Provided herein are compounds of the Formula I: [INSERT FORMULA I] and tautomers, stereoisomers and pharmaceutically acceptable salts and solvates thereof, wherein R1, R2 and Ry have the meanings given in the specification, which are inhibitors of RET kinase and are useful in the treatment and prevention of diseases which can be treated with a RET kinase inhibitor, including RET-associated diseases and disorders.

NOVEL FUSED PYRIMIDINE COMPOUND OR SALT THEREOF

The problem to be solved by the present invention is to provide a novel compound having RET inhibitory activity. The present invention also provides a pharmaceutical preparation that is useful for the prevention and/or treatment of RET-related diseases, p

N-(SUBSTITUTED-PHENYL)-SULFONAMIDE DERIVATIVES AS KINASE INHIBITORS

The invention relates to N-(substituted-phenyl)-sulfonamide compounds, which are extremely useful as inhibitors of protein kinases (e.g. PERK kinase) and accordingly can be used for the treatment of cell proliferative disorders, such as cancer, or diseases associated with activated unfolded protein response pathways, such as Alzheimer's disease. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising these compounds, and methods of treating diseases utilizing pharmaceutical compositions comprising these compounds.