21390-25-0

Usage

Uses

Used in Paint and Coating Industry:
2,6-DIMETHOXY-P-XYLENE is used as a solvent for its ability to dissolve various substances, enhancing the performance and application of paints and coatings.
Used in Adhesive Production:
2,6-DIMETHOXY-P-XYLENE is used as a solvent in the manufacturing of adhesives to improve their bonding properties and facilitate application.
Used in Dye Industry:
2,6-DIMETHOXY-P-XYLENE is used as a solvent in dye production, aiding in the dispersion and application of dyes in various materials.
Used in Pharmaceutical Manufacturing:
2,6-DIMETHOXY-P-XYLENE is used as an intermediate in the synthesis of various pharmaceutical compounds, contributing to the development of new medications.
Used in Agrochemical Production:
2,6-DIMETHOXY-P-XYLENE is used as an intermediate in the manufacturing of agrochemicals, playing a role in the development of products for agricultural applications.

InChI:InChI=1/C10H14O2/c1-7-5-9(11-3)8(2)10(6-7)12-4/h5-6H,1-4H3

Upstream product

• 6443-69-2 3,4,5-trimethoxytoluene 
• 74-88-4 methyl iodide 
• 4179-19-5 1,3-dimethoxy-5-methylbenzene 

Downstream Products

• 39581-38-9 (2,4-dimethoxy-3,6-dimethyl-phenyl)-(3-methoxy-2,5-dimethyl-phenyl)-ether 
• 859782-46-0 2-Heptadecyl-5-methoxy-3,6-dimethyl-phenol 
• 162411-67-8 2-methyl-5-phenethylbenzene-1,3-diol 
• 1361954-86-0 5-(deuteriomethyl)-1,3-dimethoxy-2-methylbenzene 
• 488-87-9 2,5-dimethyl-1,3-benzenediol 
• 60441-79-4 methyl 3,5-dimethoxy-4-methylbenzoate 
• 807628-74-6 1,3-dibromo-4,6-dimethoxy-2,5-dimethylbenzene 
• 61040-81-1 4-methyl-3,5-dimethoxybenzoic acid 
• 855954-88-0 1-(2-hydroxy-4-methoxy-3,6-dimethyl-phenyl)-heptadecan-1-one 
• 807628-69-9 3-cyano-4,6-dimethoxy-2,5-dimethylbenzaldehyde 
• 807628-78-0 3-dibromo-4,6-dimethoxy-2,5-dimethylbenzonitrile 
• 807628-84-8 3-dibromo-4,6-dimethoxy-2,5-dimethylbenzaldehyde 

Relevant academic research and scientific papers

Monocyclic Quinone Structure-Activity Patterns: Synthesis of Catalytic Inhibitors of Topoisomerase II with Potent Antiproliferative Activity

The monocyclic 1,4-benzoquinone, HU-331, the direct oxidation product of cannabidiol, inhibits the catalytic activity of topoisomerase II but without inducing DNA strand breaks or generating free radicals, and unlike many fused-ring quinones exhibits minimal cardiotoxicity. Thus, monocyclic quinones have potential as anticancer agents, and investigation of the structural origins of their biological activity is warranted. New syntheses of cannabidiol and (±)-HU-331 are here reported. Integrated synthetic protocols afforded a wide range of polysubstituted resorcinol derivatives; many of the corresponding novel 2-hydroxy-1,4-benzoquinone derivatives are potent inhibitors of the catalytic activity of topoisomerase II, some more so than HU-331, whose monoterpene unit replaced by a 3-cycloalkyl unit conferred increased antiproliferative properties in cell lines with IC50 values extending below 1 mM, and greater stability in solution than HU-331. The principal pharmacophore of quinones related to HU-331 was identified. Selected monocyclic quinones show potential for the development of new anticancer agents.

Homo- and hetero-oxidative coupling of benzyl anions

The regioselective benzylic metalation of substituted toluenes using BuLi/KO-t-Bu/TMP(H) (LiNK metalation conditions) with subsequent in situ oxidative C-C coupling has been developed for the facile generation of 1,2-diarylethanes. A range of oxidants can be used for the oxidative coupling step, with 1,2-dibromoethane proving optimal. Heterocouplings can be achieved starting from a mixture of two different toluenes with a bias toward cross coupling achievable by using a 2-fold excess of one toluene starting material. The utility of this approach is illustrated by the synthesis of several biologically active natural products. A distinct advantage is that the synthetic steps typically required to preactivate the coupling substrates are eliminated and no transition metal is required to facilitate the C-C bond formation.

New Drug Delivery System for Crossing the Blood Brain Barrier

New ubiquinol analogs are disclosed, as well as methods of using these compounds to deliver drug moieties to the body.

REGIOSELECTIVE REDUCTIVE ALKYLATION OF 1,2,3-TRIMETHOXYBENZENE

The 2-methoxyl group of 1,2,3-trimethoxybenzene and its 5-methyl-substituted homologue is removed under electron transfer conditions and replaced with an alkyl group in a one-pot procedure.