213918-78-6Relevant academic research and scientific papers
Synthesis and in vivo evaluation of 3,4-disubstituted gababutins
Blakemore, David C.,Bryans, Justin S.,Carnell, Pauline,Field, Mark J.,Kinsella, Natasha,Kinsora, Jack K.,Meltzer, Leonard T.,Osborne, Simon A.,Thompson, Lisa R.,Williams, Sophie C.
scheme or table, p. 248 - 251 (2010/04/02)
A range of 3,4-alkylated five-membered ring derivatives of gabapentin were synthesised. One compound (21) had an excellent level of potency against α2δ and was profiled in in vivo models of pain and anxiety.
Stereoelectronic effects in the reactions of conformationally restricted, substituted cyclohexane-1,2-diones with 1,2-diols
Lenz, Roman,Ley, Steven V.,Owen, Dafydd R.,Warriner, Stuart L.
, p. 2471 - 2480 (2007/10/03)
The asymmetric synthesis of a C2-symmetric cyclic 1,2-diketone is reported along with investigations into its properties as a potential asymmetric protecting group for 1,2-diols as the corresponding 1,2-diacetal.
Enantioselectivity of the Microsomal Epoxide Hydrolase Catalyzed Hydrolysis of trans-4,5-Dimethyl-1,2-epoxycyclohexane
Bellucci, Giuseppe,Berti, Giancarlo,Ferretti, Maria,Mastrorilli, Ettore,Silvestri, Luca
, p. 1471 - 1474 (2007/10/02)
The hydrolysis of the racemic and enantiomeric forms of trans-4,5-dimethyl-1,2-epoxycyclohexane, catalyzed by rabbit liver microsomal epoxide hydrolase (EH), has been investigated to clarify further the mechanism of enantioselection by this enzyme.Both ac
