15679-27-3Relevant articles and documents
Side-chain chiral centers of amino acid and helical-screw handedness of its peptides
Tanaka, Masakazu,Anan, Kosuke,Demizu, Yosuke,Kurihara, Masaaki,Doi, Mitsunobu,Suemune, Hiroshi
, p. 11570 - 11571 (2005)
Both diastereomeric right-handed (P) and left-handed (M) 310-helices exist in homopeptides having twelve chiral centers at the side-chain bicyclic skeletons. Copyright
Helical structures of bicyclic α-amino acid homochiral oligomers with the stereogenic centers at the side-chain fused-ring junctions
Anan, Kosuke,Demizu, Yosuke,Oba, Makoto,Kurihara, Masaaki,Doi, Mitsunobu,Suemune, Hiroshi,Tanaka, Masakazu
, p. 1694 - 1713 (2013/01/15)
Chiral bicyclic α-amino acid (R,R)-Ab5,6=c with stereogenic centers at the γ-position of fused-ring junctions, and its enantiomer (S,S)-Ab5,6=c, were synthesized. The CD spectra of (R,R)-Ab5,6=c oligomers indicated that th
Synthesis and in vivo evaluation of 3,4-disubstituted gababutins
Blakemore, David C.,Bryans, Justin S.,Carnell, Pauline,Field, Mark J.,Kinsella, Natasha,Kinsora, Jack K.,Meltzer, Leonard T.,Osborne, Simon A.,Thompson, Lisa R.,Williams, Sophie C.
scheme or table, p. 248 - 251 (2010/04/02)
A range of 3,4-alkylated five-membered ring derivatives of gabapentin were synthesised. One compound (21) had an excellent level of potency against α2δ and was profiled in in vivo models of pain and anxiety.