213918-77-5Relevant academic research and scientific papers
Synthesis and in vivo evaluation of 3,4-disubstituted gababutins
Blakemore, David C.,Bryans, Justin S.,Carnell, Pauline,Field, Mark J.,Kinsella, Natasha,Kinsora, Jack K.,Meltzer, Leonard T.,Osborne, Simon A.,Thompson, Lisa R.,Williams, Sophie C.
, p. 248 - 251 (2010)
A range of 3,4-alkylated five-membered ring derivatives of gabapentin were synthesised. One compound (21) had an excellent level of potency against α2δ and was profiled in in vivo models of pain and anxiety.
Stereoelectronic effects in the reactions of conformationally restricted, substituted cyclohexane-1,2-diones with 1,2-diols
Lenz, Roman,Ley, Steven V.,Owen, Dafydd R.,Warriner, Stuart L.
, p. 2471 - 2480 (2007/10/03)
The asymmetric synthesis of a C2-symmetric cyclic 1,2-diketone is reported along with investigations into its properties as a potential asymmetric protecting group for 1,2-diols as the corresponding 1,2-diacetal.
