213978-61-1

Basic information

• Product Name: (R)-4-(4-Methoxybenzyloxy)-1,2-butanediol
• Synonyms: (R)-4-(4-Methoxybenzyloxy)-1,2-butanediol;(R)-4-(4-Methoxybenzyloxy)-1,2-butanediol
• CAS NO: 213978-61-1
• Molecular Formula: C₁₂H₁₈O₄
• Molecular Weight: 226.27
• Product Categories: Chiral Building Blocks;Simple Alcohols (Chiral);Synthetic Organic Chemistry
• Mol File: 213978-61-1.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 402.297oC at 760 mmHg
• Flash Point: 197.102oC
• Appearance: /
• Density: 1.146g/cm3
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: -8 ° (C=1, CHCl3)
• CAS DataBase Reference: (R)-4-(4-Methoxybenzyloxy)-1,2-butanediol(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-4-(4-Methoxybenzyloxy)-1,2-butanediol(213978-61-1)
• EPA Substance Registry System: (R)-4-(4-Methoxybenzyloxy)-1,2-butanediol(213978-61-1)

Safety Data

• Hazardous Substances Data: 213978-61-1(Hazardous Substances Data)

Usage

General Description

(R)-4-(4-Methoxybenzyloxy)-1,2-butanediol, also known as "R(+)-2-benzyloxy-1,4-butanediol", is a chemical compound with the molecular formula C13H18O4. It is an organic compound commonly used in organic synthesis and medicinal chemistry. The compound contains a butanediol backbone with a methoxybenzyloxy group attached to one of the carbon atoms. (R)-4-(4-Methoxybenzyloxy)-1,2-butanediol may have potential applications in pharmaceutical research and drug development due to its structural properties and potential biological activities. Its specific uses and potential effects would depend on the specific application and the context in which it is used.

InChI:InChI=1/C12H18O4/c1-15-12-4-2-10(3-5-12)9-16-7-6-11(14)8-13/h2-5,11,13-14H,6-9H2,1H3/t11-/m1/s1

Upstream product

• 2746-25-0 p-Methoxybenzyl bromide 
• 142860-83-1 1-(4-methoxybenzyloxy)-3-butene 
• 119649-27-3 4-((4-methoxybenzyl)oxy)butanal 
• 824-94-2 p-methoxybenzyl chloride 
• 142860-84-2 4-(p-methoxybenzyloxy)-1,2-epoxybutane 
• 213978-60-0 (4R)-4-[2'-(4-methoxybenzyloxy)-ethyl]-2,2-dimethyl-[1,3]-dioxolane 

Downstream Products

• 1227373-89-8 (R)-1-(2-((2S,4S)-2,4,5-tris(tert-butyldimethylsilyloxy)pentyl)-1,3-dithian-2-yl)-4-(4-methoxybenzyloxy)butan-2-ol 
• 1227374-11-9 (3R,7S,9S)-1-(4-methoxybenzyloxy)-7,9,10-tris(tert-butyldimethylsilyloxy)-3-hydroxy-decan-5-one 
• 1227373-90-1 1-(((3R,5S,7R,9S)-3,5,7,9,10-pentakis(tert-butyldimethylsilyloxy)decyloxy)methyl)-4-methoxybenzene 
• 1227374-12-0 (2S,4R,6S,8R)-10-(4-methoxybenzyloxy)-2,4,6,8-tetrakis(tert-butyldimethylsilyloxy)decan-1-ol 
• 1227373-79-6 (2S,4R,6S,8R)-10-(4-methoxybenzyloxy)-2,4,6,8-tetrakis(tert-butyldimethylsilyloxy)decan-1-al 
• 1437789-15-5 (5R,9S)-7,7-diisopropyl-1-(4-methoxyphenyl)-5,9-divinyl-2,6,8-trioxa-7-silatridecane 
• 195257-62-6 (R)-2-(2-((4-methoxybenzyl)oxy)ethyl)oxirane 
• 213978-45-1 (2R)-tert-butyl-[2-methoxy-4-(4-methoxybenzyloxy)-butoxy]-diphenylsilane 
• 213978-62-2 (2R)-1-(tert-butyldiphenylsilanyloxy)-4-(4-methoxybenzyloxy)-butan-2-ol 

Relevant articles and documents

Total synthesis, biological evaluation of dendrodolides A–D and their analogues

A concise total synthesis of dendrodolides A–D (1–4) has been accomplished in 10 steps from commercially available (R)-propylene oxide and 3-buten-1-ol as starting materials. The key steps involved in the synthesis are Jacobsen hydrolytic kinetic resolution, epoxide ring opening with 2-allyl-1, 3-dithiane, Yamaguchi esterification and ring-closing metathesis (RCM). In addition, a series of ester derivatives were prepared utilizing Yamaguchi esterification at the C-3 position of the dendrodolide core and screened for their efficacy against cancer cell lines.

C(21)-C(40) of tetrafibricin via metal catalysis: Beyond stoichiometric chiral reagents, auxiliaries, and premetalated nucleophiles

Chemical equations presented. The C(21)-C(40) fragment of fibrinogen receptor inhibitor tetrafibricin was prepared in 12 steps from propane diol (longest linear sequence). In this approach, 6 C-C bonds are formed via asymmetric iridium catalyzed transfer

Synthesis of the C(18)-C(34) fragment of amphidinolide C and the C(18)-C(29) fragment of amphidinolide F

A convergent synthesis of the C(18)-C(34) fragment of amphidinolide C and the C(18)-C(29) fragment of amphidinolide F is reported. The approach involves the synthesis of the common intermediate tetrahydrofuranyl-β- ketophosphonate via cross metathesis, Pd