1437789-15-5Relevant articles and documents
Total synthesis of umuravumbolide and hyptolide through silicon-tethered ring-closing metathesis
Chowdhury, Partha Sarathi,Kumar, Pradeep
, p. 4586 - 4593 (2013/07/26)
The total synthesis of umuravumbolide and hyptolide has been achieved in a efficient manner by using temporary silicon-tethered ring-closing metathesis and cross-coupling reactions as key steps. The stereogenic centres were generated by means of proline-catalysed α-aminoxylation of aldehydes and Brown's asymmetric allylation method. An efficient total synthesis of umuravumbolide and hyptolide has been achieved by using temporary silicon-tethered ring-closing metathesis. The stereogenic centres were generated by using asymmetric allyl boration and proline-catalysed α-aminoxylation with high degrees of enantioselectivity. Copyright
