214045-73-5Relevant academic research and scientific papers
Substituted pyridine and pyrimidine derivatives and their use in treating viral infections
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, (2016/09/26)
The present invention provides compounds of Formula (I): and tautomers, isomers, and esters of said compounds, and pharmaceutically acceptable salts, solvates, and prodrugs of said compounds, wherein each of R, R1, X, Y, Z, R2, R3, R4, R5, R6, R7, R8, R9, R18, R19 and n is selected independently and as defined herein. Compositions comprising such compounds are also provided. The compounds of the invention are effective as inhibitors of HCV, and are useful, alone and together with other therapeutic agents, in treating or preventing diseases or disorders such as viral infections and virus-related disorders.
Expedient synthesis of α-(2-azaheteroaryl) acetates via the addition of silyl ketene acetals to azine- N -oxides
Londregan, Allyn T.,Burford, Kristen,Conn, Edward L.,Hesp, Kevin D.
supporting information, p. 3336 - 3339 (2014/07/08)
A new and expedient synthesis of α-(2-azaheteroaryl) acetates is presented. The reaction proceeds rapidly under mild conditions via the addition of silyl ketene acetals to azine-N-oxides in the presence of the phosphonium salt PyBroP. This procedure affords diverse α-(2-azaheteroaryl) acetates which are highly desirable components/building blocks in molecules of pharmaceutical interest but are traditionally challenging to synthesize via contemporary methods. The reaction optimization and mechanism as well as a novel electronically enhanced PyBroP derivative are described.
SUBSTITUTED PYRIDINE AND PYRIMIDINE DERIVATIVES AND THEIR USE IN TREATING VIRAL INFECTIONS
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, (2010/04/03)
The present invention provides compounds of Formula (I): and tautomers, isomers, and esters of said compounds, and pharmaceutically acceptable salts, solvates, and prodrugs of said compounds, wherein wherein each of R, R1, X, Y, Z, R2, R3, R4, R5, R6, R7, R8, R9, R18, R19 and n is selected independently and as defined herein. Compositions comprising such compounds are also provided. The compounds of the invention are effective as inhibitors of HCV, and are useful, alone and together with other therapeutic agents, in treating or preventing diseases or disorders such as viral infections and virus-related disorders.
Syntheses of 4- and 6-substituted thiazolo[4,5-c]pyridines
Huang, Yuhua,Bennett, Frank,Girijavallabhan, Vinay,Alvarez, Carmen,Chan, Tze-Ming,Osterman, Rebecca,Senior, Mary,Kwong, Cecil,Bansal, Namita,George Njoroge,MacCoss, Malcolm
scheme or table, p. 2800 - 2802 (2010/07/04)
A general synthetic approach to 4,6-substituted thiazole[4,5-c]pyridines, involving a novel one-pot thiol deprotection-cyclization key step, is described.
Novel methods to functionalize thiazolo[4,5-c]pyridines
Girijavallabhan, Vinay,Arasappan, Ashok,Bennett, Frank,Huang, Yuhua,George Njoroge,MacCoss, Malcolm
experimental part, p. 2797 - 2799 (2010/07/04)
Novel substituted thiazole[4,5-c]pyridines have been synthesized in good yields from unsubstituted thiazole[4,5-c]pyridine using direct C-H coupling reactions and N-oxide rearrangement chemistry.
