214045-74-6

Usage

Uses

Used in Drug Discovery and Development:
4-Chlorothiazolo[4,5-c]pyridine is utilized as a kinase inhibitor in drug discovery and development. Its ability to modulate cellular signaling pathways makes it a promising candidate for the treatment of various diseases, including cancer and inflammatory conditions.
Used in Organic Synthesis:
In the field of organic synthesis, 4-Chlorothiazolo[4,5-c]pyridine serves as an important building block for the production of new pharmaceuticals and agrochemicals. Its unique structure allows for the creation of novel compounds with potential therapeutic applications.
Used in Pharmaceutical Industry:
4-Chlorothiazolo[4,5-c]pyridine is used as a key intermediate in the synthesis of various pharmaceutical compounds. Its presence in these molecules can contribute to their biological activity and therapeutic efficacy.
Used in Agrochemical Industry:
4-Chlorothiazolo[4,5-c]pyridine also finds application in the agrochemical industry, where it is used as a precursor for the development of new pesticides and other agrochemical products. Its potential to act as a building block in the synthesis of these compounds can lead to the discovery of more effective and environmentally friendly solutions for agricultural challenges.

Upstream product

• 273-75-6 thiazolo[4,5-c]pyridine 
• 139460-11-0 3-amino-4-mercaptopyridine hydrochloride 
• 214045-73-5 thiazolo[4,5-c]pyridine-N-oxide 

Downstream Products

• 1332373-54-2 C₂₅H₂₆F₂N₆OS 

Relevant academic research and scientific papers

Substituted pyridine and pyrimidine derivatives and their use in treating viral infections

The present invention provides compounds of Formula (I): and tautomers, isomers, and esters of said compounds, and pharmaceutically acceptable salts, solvates, and prodrugs of said compounds, wherein each of R, R1, X, Y, Z, R2, R3, R4, R5, R6, R7, R8, R9, R18, R19 and n is selected independently and as defined herein. Compositions comprising such compounds are also provided. The compounds of the invention are effective as inhibitors of HCV, and are useful, alone and together with other therapeutic agents, in treating or preventing diseases or disorders such as viral infections and virus-related disorders.

Syntheses of 4- and 6-substituted thiazolo[4,5-c]pyridines

A general synthetic approach to 4,6-substituted thiazole[4,5-c]pyridines, involving a novel one-pot thiol deprotection-cyclization key step, is described.

Novel methods to functionalize thiazolo[4,5-c]pyridines

Novel substituted thiazole[4,5-c]pyridines have been synthesized in good yields from unsubstituted thiazole[4,5-c]pyridine using direct C-H coupling reactions and N-oxide rearrangement chemistry.

SUBSTITUTED PYRIDINE AND PYRIMIDINE DERIVATIVES AND THEIR USE IN TREATING VIRAL INFECTIONS

The present invention provides compounds of Formula (I): and tautomers, isomers, and esters of said compounds, and pharmaceutically acceptable salts, solvates, and prodrugs of said compounds, wherein wherein each of R, R1, X, Y, Z, R2, R3, R4, R5, R6, R7, R8, R9, R18, R19 and n is selected independently and as defined herein. Compositions comprising such compounds are also provided. The compounds of the invention are effective as inhibitors of HCV, and are useful, alone and together with other therapeutic agents, in treating or preventing diseases or disorders such as viral infections and virus-related disorders.