273-75-6

Usage

Uses

Used in Pharmaceutical Industry:
Thiazolo[5,4-c]pyridine is used as a key intermediate in the synthesis of various pharmaceuticals for its potential biological activities, including its anti-cancer, antimicrobial, and anti-inflammatory properties. Its incorporation into drug molecules can lead to the development of new therapeutic agents.
Used in Agrochemical Industry:
In the agrochemical sector, thiazolo[5,4-c]pyridine is utilized as a building block for the creation of novel agrochemicals, potentially enhancing crop protection and management through its biological activities against pests and diseases.
Used in Materials Science:
Thiazolo[5,4-c]pyridine is employed as a component in the development of new materials, leveraging its structural properties to improve material performance in various applications, such as in sensors or advanced composites.
Used in Coordination Chemistry:
As a ligand, thiazolo[5,4-c]pyridine is used in coordination chemistry to form complexes with metal ions, which can have applications in catalysis, molecular recognition, and the construction of functional materials.
Used in Bioimaging:
Thiazolo[5,4-c]pyridine, when designed as a fluorescent probe, is used in bioimaging to visualize and study biological processes at the molecular level, aiding in research and diagnostics.

Upstream product

• 97266-26-7 [1,3]thiazolo[4,5-c]pyridine-2-carboxylic acid 
• 38240-31-2 3-nitro-1H-pyridine-4-thione 
• 98382-93-5 4-mercapto-3-nitropyridine 
• 139460-10-9 3-(tert-Butoxycarbonylamino)-4-mercaptopyridine 
• 89786-57-2 2-methylthiazolo[4,5-c]pyridine 
• 13091-23-1 4-chloro-3-nitropyridine 
• 64-18-6 formic acid 
• 139460-11-0 3-amino-4-mercaptopyridine hydrochloride 
• 89002-13-1 3-amino-4-mercaptopyridine 
• 18504-84-2 3,3'-dinitro-4,4'-dipyridinyl disulfide 
• 56700-70-0 3-(tert-butoxycarbonylamino)pyridine 

Downstream Products

• 94391-50-1 5-methyl-4,5,6,7-tetrahydrothiazolo[4,5-c]pyridine 
• 214045-73-5 thiazolo[4,5-c]pyridine-N-oxide 
• 1208988-80-0 C₆H₄N₂OS 
• 1228149-77-6 C₁₂H₇ClN₂S 
• 1228149-73-2 2-(4-fluorophenyl)thiazolo[4,5-c]pyridine 
• 116608-16-3 2-p-tolylthiazolo<4,5-c>pyridine 
• 1228149-76-5 C₁₃H₁₀N₂OS 
• 1228149-74-3 C₁₂H₇FN₂S 
• 52334-36-8 2-(2-fluoro-phenyl)-thiazolo[4,5-c]pyridine 
• 1228149-75-4 C₁₃H₇N₃S 
• 91813-44-4 2-phenylthiazolo<4,5-c>pyridine 
• 89786-54-9 thiazolo[4,5-c]pyridine-2-ylamine 
• 1332373-54-2 C₂₅H₂₆F₂N₆OS 
• 214045-74-6 4-chlorothiazolo[4,5-c]pyridine 

Relevant academic research and scientific papers

Kinase inhibitor, and preparation and application of kinase inhibitor

The invention provides a compound shown as a formula (I), or a stereoisomer, a tautomer, nitrogen oxide, metabolite, a prodrug, pharmaceutically acceptable salt or solvate of the compound, and application of the compound to preparing drugs or drug compositions for treating Pim kinase-mediated diseases.

Substituted pyridine and pyrimidine derivatives and their use in treating viral infections

The present invention provides compounds of Formula (I): and tautomers, isomers, and esters of said compounds, and pharmaceutically acceptable salts, solvates, and prodrugs of said compounds, wherein each of R, R1, X, Y, Z, R2, R3, R4, R5, R6, R7, R8, R9, R18, R19 and n is selected independently and as defined herein. Compositions comprising such compounds are also provided. The compounds of the invention are effective as inhibitors of HCV, and are useful, alone and together with other therapeutic agents, in treating or preventing diseases or disorders such as viral infections and virus-related disorders.

COMPOUNDS FOR TREATMENT OF DRUG RESISTANT AND PERSISTENT TUBERCULOSIS

Described herein are compounds and compositions for treating drug resistant and persistent tuberculosis. Also described herein is a method of screening for identifiying biofilm formation inhibitors.

Novel methods to functionalize thiazolo[4,5-c]pyridines

Novel substituted thiazole[4,5-c]pyridines have been synthesized in good yields from unsubstituted thiazole[4,5-c]pyridine using direct C-H coupling reactions and N-oxide rearrangement chemistry.

Syntheses of 4- and 6-substituted thiazolo[4,5-c]pyridines

A general synthetic approach to 4,6-substituted thiazole[4,5-c]pyridines, involving a novel one-pot thiol deprotection-cyclization key step, is described.

SUBSTITUTED PYRIDINE AND PYRIMIDINE DERIVATIVES AND THEIR USE IN TREATING VIRAL INFECTIONS

The present invention provides compounds of Formula (I): and tautomers, isomers, and esters of said compounds, and pharmaceutically acceptable salts, solvates, and prodrugs of said compounds, wherein wherein each of R, R1, X, Y, Z, R2, R3, R4, R5, R6, R7, R8, R9, R18, R19 and n is selected independently and as defined herein. Compositions comprising such compounds are also provided. The compounds of the invention are effective as inhibitors of HCV, and are useful, alone and together with other therapeutic agents, in treating or preventing diseases or disorders such as viral infections and virus-related disorders.

DIAMINE DERIVATIVES

A compound represented by formula (1):Q1-Q2-To-N(R1) -Q3-N(R2)-T1-Q4 [wherein R1 and R2 are hydrogen atoms or the like; Q1 is a saturated or unsaturated, 5- or 6- membered cyclic hydrocarbon group which may be substituted, or the like; Q2 is a single bond or the like; Q3 represents the following group: (wherein Q5 is an alkylene group having 1 to 8 carbon atoms, or the like); and T0 and T1 are carbonyl groups or the like], a salt thereof, a solvate thereof, or an N-oxide thereof. The compound is useful as an agent for preventing and/or treating cerebral infarction, cerebral embolism, myocardial infarction, angina pectoris, pulmonary infarction, pulmonary embolism, Buerger's disease, deep venous thrombosis, disseminated intravascular coagulation syndrome, thrombus formation after artificial valve or joint replacement, thrombus formation and reocclusion after angioplasty, systemic inflammatory response syndrome (SIRS), multiple organ dysfunction syndrome (MODS), thrombus formation during extracorporeal circulation, or blood clotting upon blood drawing.

NOVEL ETHYLENEDIAMINE DERIVATIVES

A compound represented by the following formula (1):Q-Q-T-N(R)-Q-N(R)-T-Q [wherein, R1 and R2 are hydrogen atoms or the like; Q1 is a saturated or unsaturated, 5- or 6- membered cyclic hydrocarbon group which may have a substituent, or the like; Q2 is a single bond or the like; Q3 represents the following group: -C(R3a)(R4a)-{C(R3b)(R4b)}m1-{C(R3c)(R4c)}m2-{C(R3d)(R4d)}m3-{C(R3e)(R4e)}m4-C(R3f)(R4f)- (in which, R3a to R4e represent hydrogen or the like); T0 represents a carbonyl group or the like; and T1 represents -COCONR- or the like]; or salt thereof, solvate thereof, or N-oxide thereof. The compound is useful as a preventive and/or therapeutic agent for cerebral infarction, cerebral embolism, myocardial infarction, angina pectoris, pulmonary infarction, pulmonary embolism, Buerger's disease, deep venous thrombosis, disseminated intravascular coagulation syndrome, thrombus formation after valve or joint replacement, thrombus formation and reocclusion after angioplasty, systemic inflammatory response syndrome (SIRS), multiple organ dysfunction syndrome (MODS), thrombus formation during extracorporeal circulation, or blood clotting upon blood drawing.

Diamine derivatives

A compound represented by the general formula (1): Q1-Q2-T0-N(R1)-Q3-N(R2)-T1-Q4??(1) wherein R1 and R2 are hydrogen atoms or the like; Q1 is a saturated or unsaturated, 5- or 6-membered cyclic hydrocarbon group which may be substituted, or the like; Q2 is a single bond or the like; Q3 is a group in which Q5 is an alkylene group having 1 to 8 carbon atoms, or the like; and T0 and T1 are carbonyl groups or the like; a salt thereof, a solvate thereof, or an N-oxide thereof. The compound is useful as an agent for preventing and/or treating cerebral infarction, cerebral embolism, myocardial infarction, angina pectoris, pulmonary infarction, pulmonary embolism, Buerger's disease, deep venous thrombosis, disseminated intravascular coagulation syndrome, thrombus formation after valve or joint replacement, thrombus formation and reocclusion after angioplasty, systemic inflammatory response syndrome (SIRS), multiple organ dysfunction syndrome (MODS), thrombus formation during extracorporeal circulation, or blood clotting upon blood drawing.

DIAMINE DERIVATIVES

A compound represented by the general formula (1):Q1-Q2-T0-N(R1)-Q3-N(R2)-T1-Q4 wherein R1 and R2 are hydrogen atoms or the like; Q1 is a saturated or unsaturated, 5- or 6- membered cyclic hydrocarbon group which may be substituted, or the like; Q2 is a single bond or the like; Q3 is a group in which Q5 is an alkylene group having 1 to 8 carbon atoms, or the like; and T0 and T1 are carbonyl groups or the like; a salt thereof, a solvate thereof, or an N-oxide thereof. The compound is useful as an agent for preventing and/or treating cerebral infarction, cerebral embolism, myocardial infarction, angina pectoris, pulmonary infarction, pulmonary embolism, Buerger's disease, deep venous thrombosis, disseminated intravascular coagulation syndrome, thrombus formation after valve or joint replacement, thrombus formation and reocclusion after angioplasty, systemic inflammatory response syndrome (SIRS), multiple organ dysfunction syndrome (MODS), thrombus formation during extracorporeal circulation, or blood clotting upon blood drawing.