214046-52-3Relevant academic research and scientific papers
3',5'-O-phosphonoalkylidene derivatives of 1-(2-deoxy-β-D-threo- pentofuranosyl)thymine: Synthesis and reactivity
Endova, Magdalena,Masojidkova, Milena,Budesinsky, Milos,Rosenberg, Ivan
, p. 11187 - 11208 (2007/10/03)
Various 3',5'-O-(1-phosphonoalkylidene) derivatives of 1-(2-deoxy-β-D- threo-pentofuranosyl)thymine bearing a substituent in the ω-position of the alkylidene chain were prepared by the redox reaction of diethyl chlorophosphite with six-membered 3',5'-orthoesters of xylo-dT. Susceptibility of ω-haloalkylidene derivatives for nucleophilic substitution is discussed. The configuration of the final phosphonates was determined by 2D-ROESY NMR experiments.
