169382-16-5

Upstream product

• 55612-11-8 5'-O-trityldeoxyxylothymidine 
• 214046-36-3 (R)-1-[2-deoxy-3,5-O-(1-ethoxy-1-phenylmethylene)-β-threo-pentofuranosyl]thymine 
• 1663-61-2 triethoxymethylbenzene 
• 214046-52-3 (S)-1-[2-deoxy-3,5-O-(1-diethylphosphono-1-pnenylmethylene)-β-D-threo-pentofuranosyl]thymine 
• 70838-44-7 2,3'-anhydro-5'-O-benzoyl-2'-deoxythymidine 

Downstream Products

• 122621-07-2 1-(5-O-benzoyl-2,3-dideoxy-β-D-glycero-pentofuranosyl)thymine 
• 167641-89-6 3'-α-C-allenyl-5'-O-benzoyl-2',3'-dideoxythymidine 

Relevant academic research and scientific papers

3',5'-O-phosphonoalkylidene derivatives of 1-(2-deoxy-β-D-threo- pentofuranosyl)thymine: Synthesis and reactivity

Various 3',5'-O-(1-phosphonoalkylidene) derivatives of 1-(2-deoxy-β-D- threo-pentofuranosyl)thymine bearing a substituent in the ω-position of the alkylidene chain were prepared by the redox reaction of diethyl chlorophosphite with six-membered 3',5'-orthoesters of xylo-dT. Susceptibility of ω-haloalkylidene derivatives for nucleophilic substitution is discussed. The configuration of the final phosphonates was determined by 2D-ROESY NMR experiments.

Radical mediated synthesis of 3'-α-C-allenyl-2',3'-dideoxythymidine as a non-polar analogue of AZT

The synthesis of the novel modified nucleoside (1) exhibiting the 1,2- propadienyl [allenyl] group at the 3'-α-position is described. The 3'-C-C bond was formed by radical reaction between triphenylprop 2-ynylstannane (2) and the 3'-bromo(iodo)-2',3'-dide