214066-57-6

Basic information

• Product Name: 1H-Pyrrolo[1,2-c]imidazole-1,3(2H)-dione,tetrahydro-,(7aR)-(9CI)
• Synonyms: (7aR)-tetrahydro-1H-Pyrrolo[1,2-c]iMidazole-1,3(2H)-dione;1H-Pyrrolo[1,2-c]imidazole-1,3(2H)-dione,tetrahydro-,(7aR)-(9CI)
• CAS NO: 214066-57-6
• Molecular Formula: C6H8N2O2
• Molecular Weight: 140.14
• Product Categories: AMINETERTIARY
• Mol File: 214066-57-6.mol
• Article Data: 9

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1H-Pyrrolo[1,2-c]imidazole-1,3(2H)-dione,tetrahydro-,(7aR)-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrrolo[1,2-c]imidazole-1,3(2H)-dione,tetrahydro-,(7aR)-(9CI)(214066-57-6)
• EPA Substance Registry System: 1H-Pyrrolo[1,2-c]imidazole-1,3(2H)-dione,tetrahydro-,(7aR)-(9CI)(214066-57-6)

Safety Data

• Hazardous Substances Data: 214066-57-6(Hazardous Substances Data)

Usage

Structure

Tetrahydroimidazolidine ring

Type

Heterocyclic compound
Potential pharmacological properties
Possible use in medicine
Unique structure
Ongoing research for potential uses and properties in the pharmaceutical industry

Upstream product

• 344-25-2 D-Prolin 
• 590-28-3 potassium cyanate 
• 147-85-3 L-proline 
• 172876-96-9 3-oxo-1λ³-benzo[d][1,2]iodaoxole-1(3H)-carbonitrile 
• 2133-40-6 L-proline methyl ester monohydrochloride 
• 38605-65-1 (S)-1-[¹³C]carbamoylpyrrolidine-2-carboxylic acid 
• 609-36-9 rac-Pro-OH 
• 367906-67-0 N-cyanoproline methyl ester 
• 108-91-8 cyclohexylamine 
• 81965-44-8 N-(2-chloroethyl)-N-nitrosocarbamoyl prolinamide 
• 93188-01-3 2-(aminocarbonyl)-1-pyrrolidinecarboxylic acid, phenylmethyl ester 

Downstream Products

• 947150-28-9 (R)-hexahydropyrrolo[1,2-c]imidazol-3-one 
• 1000848-82-7 (±)-2-tosylhexahydro-3H-pyrrolo[1,2-c]imidazole-3-one 

Relevant articles and documents

Synthesis and crystal structure determination of hydantoin-l-proline

The title compound, hydantoin-l-proline, C6H8N 2O2, crystallize in the orthorhombic system with space group P212121 (N°19), Z = 4, and unit cell parameters a = 7.136(1) A, b = 8.009(2) A, c = 11.378(2) A. The molecular structure shows a hydantoin and pyrrolidine ring coupling forming a bicyclohydantoin. The crystal packing is governed by N-H???O hydrogen bond-type intermolecular interactions, forming infinite one-dimensional chains.

Cu-catalyzed N-3-Arylation of Hydantoins Using Diaryliodonium Salts

A general Cu-catalyzed, regioselective method for the N-3-arylation of hydantoins is described. The protocol utilizes aryl(trimethoxyphenyl)iodonium tosylate as the arylating agent in the presence of triethylamine and a catalytic amount of a simple Cu-salt. The method is compatible with structurally diverse hydantoins and operates well with neutral aryl groups or aryl groups bearing weakly donating/withdrawing elements. It is also applicable for the rapid diversification of pharmaceutically relevant hydantoins.

3-(Triflyloxy)benzynes Enable the Regiocontrolled Cycloaddition of Cyclic Ureas to Synthesize 1,4-Benzodiazepine Derivatives

A versatile synthesis of 1,4-benzodiazepine derivatives through the reaction of various 3-(trifluoromethanesulfonyloxy)benzynes with N -(p -toluenesulfonyl)imidazolidin-2-ones is reported. This reaction system provides a 1,4-benzodiazepine bearing a trifluoromethanesulfonyloxy group as a single regioisomer among the four possible regioisomers.