2141-54-0

Upstream product

• 871-29-4 trans-β-chloroacrylonitrile 
• 109-89-7 diethylamine 
• 1070-71-9 propiolonitrile 
• 7440-44-0 pyrographite 
• 372-09-8 cyanoacetic acid 

Downstream Products

• 1261032-67-0 7-amino-2-phenyl-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid ethyl ester 

Relevant academic research and scientific papers

Synthetic method for 6-trifluoromethyl-nicotinic acid

The invention discloses a method for synthesizing 6-trifluoromethyl-nicotinic acid. The method comprises the specific steps: carrying out addition-elimination reaction reactions on trifluoroacetic acid and vinyl ethyl ether under the action of phosphorus pentachloride to obtain 4-ethoxyl-1,1,1-trifluoro-3-butene-2-one; carrying out addition-elimination reaction reactions on ethidene diamine and cyanoacetic acid in a heating condition to obtain 3-(diethyl amino) acrylonitrile first; carrying out an Stork alkylation reaction on 3-(diethyl amino) acrylonitrile and 4-ethoxyl-1,1,1-trifluoro-3-butene-2-one to obtain 2-((diethyl amino) methylene)-6,6,6-trifluoro-5-oxo-3-hexenenitrile; carrying out exocondensation on 2-((diethyl amino) methylene)-6,6,6-trifluoro-5-oxo-3-hexenenitrile under the action of ammonium acetate to obtain 6-trifluoromethyl cyanopyridine; and carrying out cyano hydrolysis reaction on the 6-trifluoromethyl cyanopyridine t obtain 6-trifluoromethyl-nicotinic acid. The synthetic method is more economic, environmentally friendly, efficient and simple.

Preparation method and application of oxazoles compound with immunosuppressive activity

The invention discloses a preparation method and application of an oxazoles compound with immunosuppressive activity, and belongs to the technical field of medicine synthesis. The key point of the technical scheme is that the oxazoles compound with the immunosuppressive activity has the following structure as shown in the specification. The invention further discloses the preparation method of the oxazoles compound with the immunosuppressive activity. The oxazoles compound with the immunosuppressive activity is synthesized through a novel method; the reaction process is simple and feasible; raw materials are low in cost and readily available; the reaction efficiency and the repetitiveness are relatively high; and the immunosuppressive activity effect is obvious.

Efficient synthesis method of chromium picolinate food additive

The invention discloses an efficient synthesis method of a chromium picolinate food additive and belongs to the technical field of food additive synthesis. The chromium picolinate food additive has he following structure shown in the specification. The invention further discloses a preparation method of the chromium picolinate food additive. The chromium picolinate food additive is synthesized with a novel method, the reaction process is simple to operate and easy to implement, raw materials are easy to obtain, and the method is higher in reaction efficiency and better in repeatability, plays a good role in promoting growth of growing-finishing pigs and has very low bioaccumulation.

Triazole compound with immunosuppression activity as well as preparation method and application thereof

The invention discloses a triazole compound with immunosuppression activity as well as a preparation method and application thereof, and belongs to the technical field of medicine synthesis. According to the technical scheme of the invention, the triazole compound with immunosuppression activity is of a structure as shown in the specification. The invention further discloses a preparation method of the triazole compound with immunosuppression activity. The triazole compound with immunosuppression activity is synthesized by using a novel method, and is simple and feasible in operation in the reaction process, cheap and easy in raw material obtaining, relatively high in reaction velocity, relatively good in repeatability, and remarkable in immunosuppression activity.

BENZENE SULFONAMIDES AS CCR9 INHIBITORS

The present invention relates to compounds useful as CCR9 modulators, to compositions containing them, to methods of making them, and to methods of using them. In particular, the present invention relates to compounds capable of modulating the function of the CCR9 receptor by acting as partial agonists, antagonists or inverse agonists. Such compounds may be useful to treat, prevent or ameliorate a disease or condition associated with CCR9 activation, including inflammatory and immune disorder diseases or conditions such as inflammatory bowel diseases (IBD).

Process for the manufacture of N-(substituted)-3-aminoacrylonitriles

A process for the manufacture of N-(substituted)-3-aminoacrylonitriles of the formula N--(R1 R2)--CH=CH--CN where R1 is alkyl, phenyl, phenyl substituted with alkyl and/or --NH2 groups, or --(CH2)sub