21417-73-2

Basic information

• Product Name: Benzofuran, 2,3,5-trimethyl-
• Synonyms: Benzofuran, 2,3,5-trimethyl-
• CAS NO: 21417-73-2
• Molecular Formula: C11H12O
• Molecular Weight: 160.21
• Mol File: 21417-73-2.mol

Chemical Properties

• Boiling Point: 253.4°C at 760 mmHg
• Flash Point: 107.9°C
• Appearance: /
• Density: 1.032g/cm³
• Vapor Pressure: 0.0292mmHg at 25°C
• Refractive Index: 1.569
• CAS DataBase Reference: Benzofuran, 2,3,5-trimethyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzofuran, 2,3,5-trimethyl-(21417-73-2)
• EPA Substance Registry System: Benzofuran, 2,3,5-trimethyl-(21417-73-2)

Safety Data

• Hazardous Substances Data: 21417-73-2(Hazardous Substances Data)

Usage

InChI:InChI=1/C11H12O/c1-7-4-5-11-10(6-7)8(2)9(3)12-11/h4-6H,1-3H3

Upstream product

• 4091-39-8 3-chloro-2-butanone 
• 108-95-2 phenol 
• 106-44-5 p-cresol 
• 91969-89-0 3-(p-tolyloxy)butan-2-one 
• 917-64-6 methyl magnesium iodide 

Downstream Products

• 136795-92-1 2,3-dihydro-2,3,5-trimethyl-2,3-epoxybenzofuran 

Relevant articles and documents

One-step regioselective synthesis of benzofurans from phenols and α-Haloketones

Reported here is the direct synthesis of naphthofurans and benzofurans from readily available phenols and α-haloketones promoted by titanium tetrachloride which combines Friedel-Crafts-like alkylation and intramolecular cyclodehydration into one step. This simple protocol allows for the formation of a variety of high value naphthofurans and benzofurans within which a series of cyclic and acyclic groups are readily incorporated. This process demonstrates the advantages of high levels of regioselectivity, broad substrate scope, and moderate to excellent yields.

Titanium tetrachloride promoted cyclodehydration of aryloxyketones: Facile synthesis of benzofurans and naphthofurans with high regioselectivity

An efficient and facile method for the synthesis of a broad series of benzofurans and naphthofurans is described. The direct intramolecular cyclodehydration of aryloxyketones in the presence of titanium tetrachloride affords the corresponding benzofurans and naphthofurans with good regioselectivity and yields.

In order to phenol and α - halo as raw material synthetic benzofuran derivatives (by machine translation)

The present invention to provide a phenol and α - halo as raw materials, the role of titanium tetrachloride in the reaction of the next step high-efficient method for preparing benzofuran derivative, namely under protection of inert gas, adding phenol to and [...], then heating and stirring to reflux then adding titanium tetrachloride, finally dropping into the α - halo and [...] mixed solution, after the reaction is completed after the separation and purification to obtain the benzofuran derivatives. The synthesizing method of the invention, raw materials are easy, low cost, mild reaction conditions, the operation is simple and easy to control, less side reaction, after treatment is simple, and the product yield is high, production cost is greatly reduced, with better economic benefits, is suitable for the industrial large-scale production. (by machine translation)

Method for synthesizing benzofuran derivative by taking alpha-phenoxy-ketone as raw material

The invention discloses a method for synthesizing a benzofuran derivative by taking alpha-phenoxy-ketone as a raw material. Under shielding of inert gas, the alpha-phenoxy-ketone is dissolved in dry dichloromethane, then a mixed solution of TiCl4 and dichloromethane is dropwise added slowly, and after the indoor temperature reaction, the benzofuran derivative after separation and purification is obtained. The method for synthesizing the benzofuran derivative has the advantages that raw materials are easy to obtain, the cost is low, and reaction conditions are mild; operation is simple and easyto control, there are fewer side reactions, and the after-processing is simple; the yield of the derivative is higher, the production cost is greatly reduced, better economic benefits are achieved, and the method is suitable for industrial production.

Direct Synthesis of 2-Methylbenzofurans from Calcium Carbide and Salicylaldehyde p -Tosylhydrazones

A new methodology for the construction of methyl-substituted benzofuran rings from the reactions of calcium carbide with salicylaldehyde p-tosylhydrazones/2-hydroxyacetophenone p-tosylhydrazones is described. Various 2-methylbenzofurans and 2,3-dimethylbenzofurans could be obtained in satisfactory yield by using a cuprous chloride catalyst. The advantages of this protocol include the use of a readily available and easy-to-handle acetylene source and simple workup procedure.