214191-56-7

Usage

Uses

Used in Pharmaceutical Industry:
4,5-Imidazolidinedione, 2-methoxy-2-methylis used as an active pharmaceutical ingredient for the production of antiepileptic drugs, specifically for the treatment of certain types of epilepsy. Its ability to modulate calcium channel activity in the brain helps in managing seizure disorders.
Used in Neurological Applications:
4,5-Imidazolidinedione, 2-methoxy-2-methylis used as a neuromodulator for its potential anti-inflammatory and neuroprotective properties. This makes it a valuable chemical in the development of treatments for neurological disorders and conditions that require modulation of brain activity.
Used in Drug Research and Development:
4,5-Imidazolidinedione, 2-methoxy-2-methylis utilized in the research and development of new pharmaceuticals targeting the modulation of calcium channels and other related neurological pathways. Its potential applications in this area contribute to the advancement of treatments for various neurological conditions.

Synthetic route

acetamidine hydrochloride (124-42-5) + oxalic acid diethyl ester (95-92-1) → 2-methyl-4,5-imidazolidinedione + 2-methoxy-2-methyl-4,5-imidazolidinedione (214191-56-7)

Conditions	Yield
With methanol; sodium Cycloaddition;

methanol (67-56-1) + 2-methyl-4,5-imidazolidinedione → 2-methoxy-2-methyl-4,5-imidazolidinedione (214191-56-7)

Conditions	Yield
at 65℃; Addition;

2-methoxy-2-methyl-4,5-imidazolidinedione (214191-56-7) → 2-(dinitromethylene)-4,5-imidazolidinedione (214191-54-5)

Conditions	Yield
With sulfuric acid; nitric acid Nitration;	67%

Upstream product

• 67-56-1 methanol 
• 124-42-5 acetamidine hydrochloride 
• 95-92-1 oxalic acid diethyl ester 

Relevant academic research and scientific papers

Chemical compound suitable for use as an explosive, intermediate and method for preparing the compound

A new compound, 1,1-diamino-2,2-dinitroethylene suitable for use as an explosive, as well as an intermediate for preparing the compound consisting of a heterocyclic 5- or 6-ring of the general formula wherein n=at least 1. The compound is prepared by nitrating a heterocyclic 5- or 6-ring containing the structural element wherein Y is an alkoxy group, with a nitrating acid at a low temperature, preferably 0-30° C., and selecting the acidity of the nitrating acid for obtaining a substantial yield of a product containing the structural element and hydrolyzing said product in an aqueous medium for separating 1,1-diamino-2,2--dinitroethylene which is recovered as a precipitate.

Synthesis and reactions of 1,1-diamino-2,2-dinitroethylene

Low temperature nitrations of 2-methylimidazole gave in addition to the known 2-methyl-5(4)-nitroimidazole (1), 2- (dinitromethylene)-5,5-dinitro-4- imidazolidinone (3) and parabanic acid (2). The tetranitro compound 3 was also obtained by nitration of 2-methyl-4,5-dihydro-(1H)-5-imidazolone (8). Thermal decomposition of 3 gave 2-(dinitromethylene)-4,5-imidazolidinedione (4) which also was the product from nitration of the new compound 2-methoxy- 2-methyl-4,5- imidazolidinedione. Treatment of 4 with aqueous ammonia gave the previously unknown 1,1-diamino-2,2-dinitroethylene (5). The physical properties and chemical behaviour of (5) are described.